Abstract：
We studied the magnetic resonance spectroscopy (MRS) associations with clinicopathologic features of estrogen-dependent endometrial cancer (type I EC).
Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho peak integral to the unsuppressed water peak integral (Cho/water) of the tumor was calculated. The Cho/water and apparent diffusion coefficient (ADC) of type I EC with and without local invasion, as well as with different levels of Ki-67 staining index (SI) (≤ 40% and > 40%), were compared. Correlation test was used to examine the relationship of Cho/water, as well as mean ADC, with Ki-67 SI, tumor stage, and tumor grade.
The mean Cho/water of EC with Ki-67 SI ≤ 40% (2.28 ± 0.93) × 10-3 was lower than that with Ki-67 SI > 40% (4.08 ± 1.00) × 10-3 (P < 0.001). The mean Cho/water of EC with deep and superficial myometrial invasion was (3.41 ± 1.26) × 10-3 and (2.43 ± 1.11) × 10-3, respectively (P = 0.011). There was no significant difference in Cho/water between type I EC with and without cervical invasioin ([2.68 ± 1.00] × 10-3 and [2.77 ± 1.28] × 10-3, P = 0.866). The mean Cho/water of type I EC with and without lymph node metastasis was (4.02 ± 1.90) × 10-3 and (2.60 ± 1.06) × 10-3, respectively (P = 0.014). The Cho/water was positively correlated with the Ki-67 SI (r = 0.701, P < 0.001). There were no significant differences in ADC among groups (all P > 0.05).
MRS is helpful for preoperative assessment of clinicopathological features of type I EC.
Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho peak integral to the unsuppressed water peak integral (Cho/water) of the tumor was calculated. The Cho/water and apparent diffusion coefficient (ADC) of type I EC with and without local invasion, as well as with different levels of Ki-67 staining index (SI) (≤ 40% and > 40%), were compared. Correlation test was used to examine the relationship of Cho/water, as well as mean ADC, with Ki-67 SI, tumor stage, and tumor grade.
The mean Cho/water of EC with Ki-67 SI ≤ 40% (2.28 ± 0.93) × 10-3 was lower than that with Ki-67 SI > 40% (4.08 ± 1.00) × 10-3 (P < 0.001). The mean Cho/water of EC with deep and superficial myometrial invasion was (3.41 ± 1.26) × 10-3 and (2.43 ± 1.11) × 10-3, respectively (P = 0.011). There was no significant difference in Cho/water between type I EC with and without cervical invasioin ([2.68 ± 1.00] × 10-3 and [2.77 ± 1.28] × 10-3, P = 0.866). The mean Cho/water of type I EC with and without lymph node metastasis was (4.02 ± 1.90) × 10-3 and (2.60 ± 1.06) × 10-3, respectively (P = 0.014). The Cho/water was positively correlated with the Ki-67 SI (r = 0.701, P < 0.001). There were no significant differences in ADC among groups (all P > 0.05).
MRS is helpful for preoperative assessment of clinicopathological features of type I EC.
摘要：
我们研究了磁共振波谱（MRS）与雌激素依赖性子宫内膜癌（I型EC）的临床病理特征的关系。
共纳入45例I型EC患者，术前在3.0T接受多体素MRS。计算肿瘤的Cho峰积分与未抑制的水峰积分的平均比率(Cho/水)。有和没有局部侵入的I型EC的Cho/水和表观扩散系数（ADC），以及不同水平的Ki-67染色指数（SI）（≤40％和>40％），进行了比较。相关性检验用于检验Cho/水的关系，以及平均ADC，Ki-67SI，肿瘤分期,和肿瘤等级。
Ki-67SI≤40％（2.28±0.93）×10-3的EC平均Cho/水低于Ki-67SI>40％（4.08±1.00）×10-3（P<0.001）。子宫肌层深部和浅表浸润EC的平均Cho/水分别为（3.41±1.26）×10-3和（2.43±1.11）×10-3（P=0.011）。有和无宫颈浸润的I型EC的Cho/水差异无统计学意义（[2.68±1.00]×10-3和[2.77±1.28]×10-3，P=0.866）。有淋巴结转移和无淋巴结转移的I型EC的平均Cho/水分别为（4.02±1.90）×10-3和（2.60±1.06）×10-3（P=0.014）。Cho/水与Ki-67SI呈正相关(r=0.701,P<0.001)。各组间ADC值差异无统计学意义(均P>0.05)。
MRS有助于术前评估I型EC的临床病理特征。
共纳入45例I型EC患者，术前在3.0T接受多体素MRS。计算肿瘤的Cho峰积分与未抑制的水峰积分的平均比率(Cho/水)。有和没有局部侵入的I型EC的Cho/水和表观扩散系数（ADC），以及不同水平的Ki-67染色指数（SI）（≤40％和>40％），进行了比较。相关性检验用于检验Cho/水的关系，以及平均ADC，Ki-67SI，肿瘤分期,和肿瘤等级。
Ki-67SI≤40％（2.28±0.93）×10-3的EC平均Cho/水低于Ki-67SI>40％（4.08±1.00）×10-3（P<0.001）。子宫肌层深部和浅表浸润EC的平均Cho/水分别为（3.41±1.26）×10-3和（2.43±1.11）×10-3（P=0.011）。有和无宫颈浸润的I型EC的Cho/水差异无统计学意义（[2.68±1.00]×10-3和[2.77±1.28]×10-3，P=0.866）。有淋巴结转移和无淋巴结转移的I型EC的平均Cho/水分别为（4.02±1.90）×10-3和（2.60±1.06）×10-3（P=0.014）。Cho/水与Ki-67SI呈正相关(r=0.701,P<0.001)。各组间ADC值差异无统计学意义(均P>0.05)。
MRS有助于术前评估I型EC的临床病理特征。
