Abstract：
BACKGROUND: Artesunate, as a semi-synthetic artemisinin derivative of sesquiterpene lactone, is widely used in clinical antimalarial treatment due to its endoperoxide group. Recent studies have found that artesunate may have multiple pharmacological effects, indicating its significant therapeutic potential in multiple respiratory diseases.
OBJECTIVE: This review aims to summarize proven and potential therapeutic effects of artesunate in common respiratory disorders.
METHODS: This review summarizes the pharmacological properties of artesunate and then interprets the function of artesunate in various respiratory diseases in detail, such as bronchial asthma, chronic obstructive pulmonary disease, lung injury, lung cancer, pulmonary fibrosis, coronavirus disease 2019, etc., on different target cells and receptors according to completed and ongoing in silico, in vitro, and in vivo studies (including clinical trials).
METHODS: Literature was searched in electronic databases, including Pubmed, Web of Science and CNKI with the primary keywords of \'artesunate\', \'pharmacology\', \'pharmacokinetics\', \'respiratory disorders\', \'lung\', \'pulmonary\', and secondary search terms of \'Artemisia annua L.\', \'artemisinin\', \'asthma\', \'chronic obstructive lung disease\', \'lung injury\', \'lung cancer\', \'pulmonary fibrosis\', \'COVID-19\' and \'virus\' in English and Chinese. All experiments were included. Reviews and irrelevant studies to the therapeutic effects of artesunate on respiratory diseases were excluded. Information was sort out according to study design, subject, intervention, and outcome.
RESULTS: Artesunate is promising to treat multiple common respiratory disorders via various mechanisms, such as anti-inflammation, anti-oxidative stress, anti-hyperresponsiveness, anti-proliferation, airway remodeling reverse, induction of cell death, cell cycle arrest, etc. CONCLUSION: Artesunate has great potential to treat various respiratory diseases.
OBJECTIVE: This review aims to summarize proven and potential therapeutic effects of artesunate in common respiratory disorders.
METHODS: This review summarizes the pharmacological properties of artesunate and then interprets the function of artesunate in various respiratory diseases in detail, such as bronchial asthma, chronic obstructive pulmonary disease, lung injury, lung cancer, pulmonary fibrosis, coronavirus disease 2019, etc., on different target cells and receptors according to completed and ongoing in silico, in vitro, and in vivo studies (including clinical trials).
METHODS: Literature was searched in electronic databases, including Pubmed, Web of Science and CNKI with the primary keywords of \'artesunate\', \'pharmacology\', \'pharmacokinetics\', \'respiratory disorders\', \'lung\', \'pulmonary\', and secondary search terms of \'Artemisia annua L.\', \'artemisinin\', \'asthma\', \'chronic obstructive lung disease\', \'lung injury\', \'lung cancer\', \'pulmonary fibrosis\', \'COVID-19\' and \'virus\' in English and Chinese. All experiments were included. Reviews and irrelevant studies to the therapeutic effects of artesunate on respiratory diseases were excluded. Information was sort out according to study design, subject, intervention, and outcome.
RESULTS: Artesunate is promising to treat multiple common respiratory disorders via various mechanisms, such as anti-inflammation, anti-oxidative stress, anti-hyperresponsiveness, anti-proliferation, airway remodeling reverse, induction of cell death, cell cycle arrest, etc. CONCLUSION: Artesunate has great potential to treat various respiratory diseases.
摘要：
背景：青蒿琥酯，作为倍半萜内酯的半合成青蒿素衍生物，由于其内过氧化物基团，被广泛用于临床抗疟治疗。最近的研究发现青蒿琥酯可能具有多种药理作用,表明其在多种呼吸系统疾病中具有重要的治疗潜力。
目的：本综述旨在总结青蒿琥酯在常见呼吸系统疾病中已证实和潜在的治疗作用。
方法：本文总结了青蒿琥酯的药理特性，然后详细解释了青蒿琥酯在各种呼吸系统疾病中的作用。比如支气管哮喘，慢性阻塞性肺疾病,肺损伤,肺癌,肺纤维化，2019年冠状病毒病等。,根据已完成和正在进行的计算机模拟，在不同的靶细胞和受体上，在体外，和体内研究（包括临床试验）。
方法：在电子数据库中搜索文献，包括Pubmed,WebofScience和CNKI，主要关键词为“artesunate”，\'药理学\',“药代动力学”，\'呼吸系统疾病\',\'肺\',\'肺\',和“青蒿L.”的二级搜索词，\'青蒿素\',\'哮喘\',“慢性阻塞性肺疾病”，\'肺损伤\',\'肺癌\',\'肺纤维化\',\'COVID-19\'和\'病毒\'中英文。包括所有实验。青蒿琥酯对呼吸系统疾病的治疗作用的评论和不相关的研究被排除在外。根据研究设计整理了信息，主题,干预，和结果。
结果：青蒿琥酯有望通过各种机制治疗多种常见的呼吸系统疾病，如抗炎，抗氧化应激，抗高反应性，防扩散,气道重塑逆转，诱导细胞死亡，细胞周期停滞,等。结论：青蒿琥酯具有治疗多种呼吸系统疾病的巨大潜力。
目的：本综述旨在总结青蒿琥酯在常见呼吸系统疾病中已证实和潜在的治疗作用。
方法：本文总结了青蒿琥酯的药理特性，然后详细解释了青蒿琥酯在各种呼吸系统疾病中的作用。比如支气管哮喘，慢性阻塞性肺疾病,肺损伤,肺癌,肺纤维化，2019年冠状病毒病等。,根据已完成和正在进行的计算机模拟，在不同的靶细胞和受体上，在体外，和体内研究（包括临床试验）。
方法：在电子数据库中搜索文献，包括Pubmed,WebofScience和CNKI，主要关键词为“artesunate”，\'药理学\',“药代动力学”，\'呼吸系统疾病\',\'肺\',\'肺\',和“青蒿L.”的二级搜索词，\'青蒿素\',\'哮喘\',“慢性阻塞性肺疾病”，\'肺损伤\',\'肺癌\',\'肺纤维化\',\'COVID-19\'和\'病毒\'中英文。包括所有实验。青蒿琥酯对呼吸系统疾病的治疗作用的评论和不相关的研究被排除在外。根据研究设计整理了信息，主题,干预，和结果。
结果：青蒿琥酯有望通过各种机制治疗多种常见的呼吸系统疾病，如抗炎，抗氧化应激，抗高反应性，防扩散,气道重塑逆转，诱导细胞死亡，细胞周期停滞,等。结论：青蒿琥酯具有治疗多种呼吸系统疾病的巨大潜力。
