PDF(Pubmed)
Abstract：
Aging is accompanied by many changes in brain and contributes to progressive cognitive decline. In contrast to pathological changes in brain, normal aging brain changes have relatively mild but important changes in structural, biochemical and molecular level. Representatively, aging associated brain changes include atrophy of tissues, alteration in neurotransmitters and damage accumulation in cellular environment. These effects have causative link with age associated changes which ultimately results in cognitive decline. Although several evidences were found in normal aging changes of brain, it is not clearly integrated. Figuring out aging related changes in brain is important as aging is the process that everyone goes through, and comprehensive understanding may help to progress further studies. This review clarifies normal aging brain changes in an asymptotic and comprehensive manner, from a gross level to a microscopic and molecular level, and discusses potential approaches to seek the changes with cognitive decline.
摘要：
衰老伴随着大脑的许多变化，并导致进行性认知能力下降。与大脑的病理变化相反，正常衰老的大脑结构变化相对温和但重要，生化和分子水平。代表性地,衰老相关的大脑变化包括组织萎缩，细胞环境中神经递质的改变和损伤积累。这些影响与年龄相关的变化有因果关系，最终导致认知能力下降。尽管在大脑的正常老化变化中发现了一些证据，它没有明确的整合。了解大脑中与衰老相关的变化很重要，因为衰老是每个人都经历的过程，全面的了解可能有助于进一步的研究。这篇综述以渐进和全面的方式阐明了正常的衰老大脑变化，从总体水平到微观和分子水平，并讨论了寻求认知衰退变化的潜在方法。
