PDF(Pubmed)
Abstract：
Chronic rotator cuff tears are debilitating diseases which significantly affect patients\' quality of life and pose substantial financial burden to the society. The intraoperative reparability of injured tendon and postoperative probability of tendon retear are highly associated with the quality of torn muscles, specifically, the severity of muscle atrophy and fatty infiltration. Animal models that reproduce the characteristic muscle pathology after rotator cuff injury have been developed and used to provide insight into the underlying biology and pathophysiology. In this review, we briefly summarize the current information obtained from preclinical animal studies regarding the degenerative change of cuff muscle subsequent to tendon release and/or suprascapular nerve denervation. Importantly, we focus on the potential translational therapeutic targets or agents for the prevention or reversal of muscle atrophy and fatty infiltration. While further studies are warranted to assess the safety and efficacy of novel therapies derived from these preclinical animal research, we believe that their clinical translation for the treatment of rotator cuff disorders is on the horizon.
UNASSIGNED: Novel therapeutic strategies described in this review from preclinical animal studies hold a great translational potential for preventing or reversing rotator cuff muscle pathology, while further assessments on their safety and efficacy are warranted.
UNASSIGNED: Novel therapeutic strategies described in this review from preclinical animal studies hold a great translational potential for preventing or reversing rotator cuff muscle pathology, while further assessments on their safety and efficacy are warranted.
摘要：
慢性肩袖撕裂是一种使人衰弱的疾病，严重影响患者的生活质量，给社会带来巨大的经济负担。损伤肌腱的术中修复能力和术后肌腱再撕裂的概率与肌肉撕裂的质量高度相关。具体来说,肌肉萎缩和脂肪浸润的严重程度。已经开发了再现肩袖损伤后特征性肌肉病理的动物模型，并将其用于深入了解潜在的生物学和病理生理学。在这次审查中,我们简要总结了从临床前动物研究中获得的有关肌腱释放和/或肩胛骨上神经支配后袖带肌退行性改变的最新信息。重要的是,我们关注的是预防或逆转肌肉萎缩和脂肪浸润的潜在转化治疗靶点或药物.虽然需要进一步的研究来评估来自这些临床前动物研究的新疗法的安全性和有效性，我们相信，他们的临床翻译治疗肩袖疾病是在地平线上。
■本综述中描述的来自临床前动物研究的新治疗策略对于预防或逆转肩袖肌肉病理具有巨大的转化潜力，虽然有必要对其安全性和有效性进行进一步评估。
■本综述中描述的来自临床前动物研究的新治疗策略对于预防或逆转肩袖肌肉病理具有巨大的转化潜力，虽然有必要对其安全性和有效性进行进一步评估。
