PDF(Pubmed)
Abstract：
UNASSIGNED: We sought to review the latest developments in cortical visual prosthesis (CVP) systems and the significance of nanotechnology for the future. Over the past century, CVP systems have been researched and developed, resulting in various unique surgical and mechanical techniques. Research findings indicate that partial vision recovery is possible, with improvements in coarse target functions and performance in routine activities.
UNASSIGNED: This review discusses the architecture and physiology of the visual cortex, the neuroplasticity of the blind brain, and the history of CVP development, and also provides an update on the CVP systems currently being examined in research and clinical trials. Due to advances in nanotechnology, it is possible to make CVPs that are smaller, more efficient, and more biocompatible than ever before.
UNASSIGNED: Currently, 3 CVPs have entered clinical trials, and several additional systems are undergoing preclinical reviews to determine the safety of the devices for chronic implantation. This development provides the first indication that the area of cortical vision restoration medication may be able to meaningfully benefit blind people. However, several significant technical and biological challenges need to be solved before the gap between artificial and natural eyesight can be reconciled. Rapid breakthroughs in nanotechnology have considerably increased its use in biological domains.
UNASSIGNED: This paper summarizes the recent progress of CVP in recent years and its future development direction. It is forecasted that nanotechnology can provide better technical support for the development of CVP.
UNASSIGNED: This review discusses the architecture and physiology of the visual cortex, the neuroplasticity of the blind brain, and the history of CVP development, and also provides an update on the CVP systems currently being examined in research and clinical trials. Due to advances in nanotechnology, it is possible to make CVPs that are smaller, more efficient, and more biocompatible than ever before.
UNASSIGNED: Currently, 3 CVPs have entered clinical trials, and several additional systems are undergoing preclinical reviews to determine the safety of the devices for chronic implantation. This development provides the first indication that the area of cortical vision restoration medication may be able to meaningfully benefit blind people. However, several significant technical and biological challenges need to be solved before the gap between artificial and natural eyesight can be reconciled. Rapid breakthroughs in nanotechnology have considerably increased its use in biological domains.
UNASSIGNED: This paper summarizes the recent progress of CVP in recent years and its future development direction. It is forecasted that nanotechnology can provide better technical support for the development of CVP.
摘要：
■我们试图回顾皮质视觉假体（CVP）系统的最新发展以及纳米技术对未来的意义。在过去的一个世纪里,CVP系统已经研究和开发，导致各种独特的手术和机械技术。研究结果表明，部分视力恢复是可能的，改善了粗略的目标函数和日常活动的性能。
■这篇综述讨论了视觉皮层的结构和生理学，盲人大脑的神经可塑性，以及CVP发展的历史，并提供了目前正在研究和临床试验中检查的CVP系统的更新。由于纳米技术的进步，有可能使CVPs更小，更有效率,比以往任何时候都更具生物相容性。
■目前，3个CVP已经进入临床试验，和几个额外的系统正在进行临床前审查，以确定慢性植入装置的安全性。这一发展提供了第一个迹象，表明皮质视力恢复药物可能能够对盲人有益。然而,在协调人工视力和自然视力之间的差距之前，需要解决几个重大的技术和生物学挑战。纳米技术的迅速突破大大增加了其在生物学领域的应用。
■本文总结了近年来CVP的最新进展及其未来的发展方向。预计纳米技术可以为CVP的发展提供更好的技术支持。
■这篇综述讨论了视觉皮层的结构和生理学，盲人大脑的神经可塑性，以及CVP发展的历史，并提供了目前正在研究和临床试验中检查的CVP系统的更新。由于纳米技术的进步，有可能使CVPs更小，更有效率,比以往任何时候都更具生物相容性。
■目前，3个CVP已经进入临床试验，和几个额外的系统正在进行临床前审查，以确定慢性植入装置的安全性。这一发展提供了第一个迹象，表明皮质视力恢复药物可能能够对盲人有益。然而,在协调人工视力和自然视力之间的差距之前，需要解决几个重大的技术和生物学挑战。纳米技术的迅速突破大大增加了其在生物学领域的应用。
■本文总结了近年来CVP的最新进展及其未来的发展方向。预计纳米技术可以为CVP的发展提供更好的技术支持。
