Abstract：
OBJECTIVE: The neurotropism of SARS-CoV-2 and the consequential damage to the olfactory system have been proposed as one of the possible underlying causes of olfactory dysfunction in COVID-19. We aimed to aggregate the results of the studies which reported imaging of the olfactory system of patients with COVID-19 versus controls.
METHODS: PubMed and EMBASE were searched to identify relevant literature reporting the structural imaging characteristics of the olfactory bulb (OB), olfactory cleft, olfactory sulcus (OS), or olfactory tract in COVID-19 patients. Hedge\'s g and weighted mean difference were used as a measure of effect size. Quality assessment, subgroup analyses, meta-regression, and sensitivity analysis were also conducted.
RESULTS: Ten studies were included in the qualitative synthesis, out of which seven studies with 183 cases with COVID-19 and 308 controls without COVID-19 were enrolled in the quantitative synthesis. No significant differences were detected in analyses of right OB volume and left OB volume. Likewise, right OS depth and left OS depth were also not significantly different in COVID-19 cases compared to non-COVID-19 controls. Also, we performed subgroup analysis, meta-regression, and sensitivity analysis to investigate the potential effect of confounding moderators.
CONCLUSIONS: The findings of this review did not confirm alterations in structural imaging of the olfactory system, including OB volume and OS depth by Covid-19 which is consistent with the results of recent histopathological evaluations.
METHODS: PubMed and EMBASE were searched to identify relevant literature reporting the structural imaging characteristics of the olfactory bulb (OB), olfactory cleft, olfactory sulcus (OS), or olfactory tract in COVID-19 patients. Hedge\'s g and weighted mean difference were used as a measure of effect size. Quality assessment, subgroup analyses, meta-regression, and sensitivity analysis were also conducted.
RESULTS: Ten studies were included in the qualitative synthesis, out of which seven studies with 183 cases with COVID-19 and 308 controls without COVID-19 were enrolled in the quantitative synthesis. No significant differences were detected in analyses of right OB volume and left OB volume. Likewise, right OS depth and left OS depth were also not significantly different in COVID-19 cases compared to non-COVID-19 controls. Also, we performed subgroup analysis, meta-regression, and sensitivity analysis to investigate the potential effect of confounding moderators.
CONCLUSIONS: The findings of this review did not confirm alterations in structural imaging of the olfactory system, including OB volume and OS depth by Covid-19 which is consistent with the results of recent histopathological evaluations.
摘要：
目的：SARS-CoV-2的神经嗜性和对嗅觉系统的相应损害已被认为是COVID-19嗅觉功能障碍的潜在原因之一。我们旨在汇总报道COVID-19患者与对照组嗅觉系统成像的研究结果。
方法：检索PubMed和EMBASE以确定报告嗅球（OB）结构成像特征的相关文献，嗅裂,嗅沟（OS），或COVID-19患者的嗅道。对冲的g和加权平均差被用作效应大小的度量。质量评估,亚组分析，元回归，并进行了敏感性分析。
结果：定性综合纳入了10项研究，其中7项研究纳入了183例COVID-19病例和308例不含COVID-19的对照。在右OB体积和左OB体积的分析中没有检测到显著差异。同样，与非COVID-19对照组相比，COVID-19病例的右OS深度和左OS深度也没有显着差异。此外，我们进行了亚组分析，元回归，和敏感性分析，以研究混杂调节因素的潜在影响。
结论：本综述的结果未证实嗅觉系统的结构成像改变，包括Covid-19的OB体积和OS深度，这与最近的组织病理学评估结果一致。
方法：检索PubMed和EMBASE以确定报告嗅球（OB）结构成像特征的相关文献，嗅裂,嗅沟（OS），或COVID-19患者的嗅道。对冲的g和加权平均差被用作效应大小的度量。质量评估,亚组分析，元回归，并进行了敏感性分析。
结果：定性综合纳入了10项研究，其中7项研究纳入了183例COVID-19病例和308例不含COVID-19的对照。在右OB体积和左OB体积的分析中没有检测到显著差异。同样，与非COVID-19对照组相比，COVID-19病例的右OS深度和左OS深度也没有显着差异。此外，我们进行了亚组分析，元回归，和敏感性分析，以研究混杂调节因素的潜在影响。
结论：本综述的结果未证实嗅觉系统的结构成像改变，包括Covid-19的OB体积和OS深度，这与最近的组织病理学评估结果一致。
