Abstract：
BACKGROUND: To establish and verify the accuracy and reliability of a sulcus-to-sulcus diameter (STS) prediction model.
METHODS: In this retrospective study, the prediction formula was established with the data from 1466 eyes from 733 subjects from July 2020 to April 2021 and verified with the data from 278 eyes from 139 subjects between May 2021 and June 2021. Each subject was measured with a Pentacam, IOLMaster 700, OPD-Scan III, and ultrasound biomicroscope. The prediction formulas were established with multiple linear regression, and intergroup correlation coefficients (ICCs) and Bland-Altman tests were used to assess the agreement between the predicted and actual STS (actual STS was measured by UBM).
RESULTS: The explanatory variables relevant to the horizontal STS (STSH) were the Pentacam white-to-white diameter (WTWP; standardized partial regression coefficient [β] = 0.330; p < 0.001), the flat K value (β = -0.211; p < 0.001), and the anterior corneal diameter (ACD) (β = 0.178; p < 0.001). The corresponding multiple regression equation was : STSH (mm) = 8.061 + 0.510 × WTWP - 0.090 × Flat K value + 0.430 × ACD. The explanatory variables relevant to the vertical STS (STSV) were the WTWP (β = 0.435; p < 0.001), the steep K value (β = -0.271; p < 0.001), and the ACD (β = 0.187; p < 0.001). The corresponding multiple regression equation was : STSV (mm) = 8.540 + 0.492 × WTWP - 0.075 × Steep K value + 0.329 × ACD. The bias of the predicted to the actual STSH was - 0.021, with 95% limits of agreement (95% LoA) from - 0.499 to 0.457. The bias of the predicted to the actual STSV was 0.057, with 95% LoA from - 0.462 to 0.575. The ICC was 0.883 between the predicted and actual STSH and 0.859 between the predicted and actual STSV.
CONCLUSIONS: The Pentacam-measured WTW, the K value and the ACD are important for predicting the STS diameter. The prediction model has good accuracy and reliability.
BACKGROUND: Not applicable.
METHODS: In this retrospective study, the prediction formula was established with the data from 1466 eyes from 733 subjects from July 2020 to April 2021 and verified with the data from 278 eyes from 139 subjects between May 2021 and June 2021. Each subject was measured with a Pentacam, IOLMaster 700, OPD-Scan III, and ultrasound biomicroscope. The prediction formulas were established with multiple linear regression, and intergroup correlation coefficients (ICCs) and Bland-Altman tests were used to assess the agreement between the predicted and actual STS (actual STS was measured by UBM).
RESULTS: The explanatory variables relevant to the horizontal STS (STSH) were the Pentacam white-to-white diameter (WTWP; standardized partial regression coefficient [β] = 0.330; p < 0.001), the flat K value (β = -0.211; p < 0.001), and the anterior corneal diameter (ACD) (β = 0.178; p < 0.001). The corresponding multiple regression equation was : STSH (mm) = 8.061 + 0.510 × WTWP - 0.090 × Flat K value + 0.430 × ACD. The explanatory variables relevant to the vertical STS (STSV) were the WTWP (β = 0.435; p < 0.001), the steep K value (β = -0.271; p < 0.001), and the ACD (β = 0.187; p < 0.001). The corresponding multiple regression equation was : STSV (mm) = 8.540 + 0.492 × WTWP - 0.075 × Steep K value + 0.329 × ACD. The bias of the predicted to the actual STSH was - 0.021, with 95% limits of agreement (95% LoA) from - 0.499 to 0.457. The bias of the predicted to the actual STSV was 0.057, with 95% LoA from - 0.462 to 0.575. The ICC was 0.883 between the predicted and actual STSH and 0.859 between the predicted and actual STSV.
CONCLUSIONS: The Pentacam-measured WTW, the K value and the ACD are important for predicting the STS diameter. The prediction model has good accuracy and reliability.
BACKGROUND: Not applicable.
摘要：
背景：建立并验证一种沟-沟直径（STS）预测模型的准确性和可靠性。
方法：在这项回顾性研究中，该预测公式是根据2020年7月至2021年4月733名受试者的1466只眼睛的数据建立的，并根据2021年5月至2021年6月139名受试者的278只眼睛的数据进行验证。每个受试者都用Pentacam测量，IOLMaster700,OPD-ScanIII,和超声生物显微镜。采用多元线性回归建立预测公式,以及组间相关系数（ICC）和Bland-Altman检验用于评估预测和实际STS之间的一致性（实际STS由UBM测量）。
结果：与水平STS（STSH）相关的解释变量是Pentacam白色至白色直径（WTWP；标准化部分回归系数[β]=0.330；p<0.001），平坦K值(β=-0.211；p<0.001)，和角膜前直径（ACD）（β=0.178；p<0.001）。相应的多元回归方程为:STSH(mm)=8.061+0.510×WTWP-0.090×平K值+0.430×ACD。与垂直STS(STSV)相关的解释变量是WTWP(β=0.435；p<0.001)，陡峭的K值(β=-0.271；p<0.001)，和ACD(β=0.187；p<0.001)。相应的多元回归方程为：STSV（mm）=8.5400.492×WTWP-0.075×陡峭K值0.329×ACD。预测对实际STSH的偏倚为-0.021,95%的一致性限制(95%LoA)从-0.499到0.457。预测的实际STSV的偏差为0.057,95%LoA为-0.462至0.575。ICC在预测和实际STSH之间为0.883,在预测和实际STSV之间为0.859。
结论：Pentacam测量的WTW，K值和ACD对于预测STS直径很重要。该预测模型具有较好的准确性和可靠性。
背景：不适用。
方法：在这项回顾性研究中，该预测公式是根据2020年7月至2021年4月733名受试者的1466只眼睛的数据建立的，并根据2021年5月至2021年6月139名受试者的278只眼睛的数据进行验证。每个受试者都用Pentacam测量，IOLMaster700,OPD-ScanIII,和超声生物显微镜。采用多元线性回归建立预测公式,以及组间相关系数（ICC）和Bland-Altman检验用于评估预测和实际STS之间的一致性（实际STS由UBM测量）。
结果：与水平STS（STSH）相关的解释变量是Pentacam白色至白色直径（WTWP；标准化部分回归系数[β]=0.330；p<0.001），平坦K值(β=-0.211；p<0.001)，和角膜前直径（ACD）（β=0.178；p<0.001）。相应的多元回归方程为:STSH(mm)=8.061+0.510×WTWP-0.090×平K值+0.430×ACD。与垂直STS(STSV)相关的解释变量是WTWP(β=0.435；p<0.001)，陡峭的K值(β=-0.271；p<0.001)，和ACD(β=0.187；p<0.001)。相应的多元回归方程为：STSV（mm）=8.5400.492×WTWP-0.075×陡峭K值0.329×ACD。预测对实际STSH的偏倚为-0.021,95%的一致性限制(95%LoA)从-0.499到0.457。预测的实际STSV的偏差为0.057,95%LoA为-0.462至0.575。ICC在预测和实际STSH之间为0.883,在预测和实际STSV之间为0.859。
结论：Pentacam测量的WTW，K值和ACD对于预测STS直径很重要。该预测模型具有较好的准确性和可靠性。
背景：不适用。
