Abstract：
Narrowband UVB (NB-UVB) has been shown to be effective for the treatment of early mycosis fungoides (MF) in light-skinned patients, but the effect of NB-UVB on patients with darker skin phototypes needs further investigation. The aim of this study was to evaluate the effect of NB-UVB in the treatment of early-stage MF in Iranian patients. In this retrospective study, 24 patients with the diagnosis of early MF (9 stage AI, 15 stage IB) were enrolled. All patients were treated with NB-UVB phototherapy 2-3 times weekly. After achieving complete response, a maintenance treatment was recommended. The response rate, side effects, and recurrence rate in the follow-up period were assessed. The follow-up period was ranged 6 to 24 months. Ten patients (41.7%) had complete remission after a mean number of 42.9 treatment and mean cumulative dose of 58.11 J/cm2. Twelve patients (50%) had partial response, and 2 patients (8.3%) had no response. After discontinuation of maintenance treatment, 4 of 10 patients (40%) with complete remission relapsed within a mean of 5 months. Side effects were limited to erythema (12.5%) and hyperpigmentation (4%). NB-UVB is a safe and effective method for the treatment of early MF, but it seems that more treatment sessions and higher doses of NB-UVB are required for darker skin phototypes.
摘要：
窄频带UVB（NB-UVB）已被证明可有效治疗浅皮肤患者的早期真菌病（MF），但是NB-UVB对深色皮肤光型患者的影响需要进一步研究。这项研究的目的是评估NB-UVB在伊朗患者早期MF治疗中的作用。在这项回顾性研究中,24例诊断为早期MF（9期AI，15期IB)被登记。所有患者均接受NB-UVB光疗，每周2-3次。完成响应后，建议进行维持治疗.响应率，副作用,并评估随访期间的复发率。随访时间6～24个月。10例患者（41.7％）在平均治疗人数为42.9，平均累积剂量为58.11J/cm2后完全缓解。12例患者（50%）有部分反应，2例患者（8.3％）无反应。停止维持治疗后，10例完全缓解患者中有4例（40％）在平均5个月内复发。副作用仅限于红斑（12.5％）和色素沉着过度（4％）。NB-UVB是治疗早期MF的安全有效方法,但似乎需要更多的治疗时间和更高剂量的NB-UVB对于较深的皮肤照型是必需的。
