PDF(Pubmed)
Abstract：
Adsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, treatment and clinical course. Dermatological diseases, in which GMA has been performed, include generalized pustular psoriasis, pyoderma gangrenosum, palmoplantar pustular psoriasis, Behcet\'s disease, Sweet\'s syndrome, adult-onset Still\'s disease, impetigo herpetiformis, reactive arthritis, acne and hidradenitis suppurativa syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus. In most patients, GMA was started after the failure of conventional therapeutic options and it was helpful in the majority of cases. Based on the information summarized, GMA could be considered a valid non-pharmacological treatment option for patients with several dermatological conditions, which are difficult to treat with other pharmacological preparations.
摘要：
吸附粒细胞和单核细胞分离术（GMA）是一种体外治疗方法，可选择性地从外周血中去除活化的髓系白细胞。该技术由带有醋酸纤维素珠作为吸收性白细胞提取载体的色谱柱组成，最初用于治疗溃疡性结肠炎。进行了文献检索，以提取最近发表的有关GMA在不同皮肤病患者中的临床疗效的研究，报告人口统计信息，临床症状,治疗和临床过程。皮肤病,GMA已经完成，包括全身性脓疱型银屑病,坏疽性脓皮病,掌足底脓疱型银屑病，Behcet病,甜蜜综合症，成人发作的斯蒂尔病，脓疱疮,反应性关节炎,痤疮和化脓性汗腺炎综合征，皮肤过敏性血管炎和系统性红斑狼疮。在大多数患者中，GMA是在常规治疗选择失败后开始的，在大多数情况下都有帮助。根据汇总的信息，对于患有多种皮肤病的患者，GMA可以被认为是一种有效的非药物治疗选择。用其他药物制剂很难治疗。
