Abstract：
OBJECTIVE: This study evaluated psychometric properties of the Pediatric Narcolepsy Screening Questionnaire (PNSQ), developed in response to the difficulty of identifying pediatric narcolepsy.
METHODS: The initial PNSQ was updated following debriefing interviews with parents of children with suspected/diagnosed narcolepsy. Subsequently, newly recruited caregivers were categorized into groups: clinician-confirmed narcolepsy, other sleep problems (OSP), and no sleep problems (controls). Caregivers completed the 11-item PNSQ assessing narcolepsy symptomatology. PNSQ psychometric properties were evaluated; mean PNSQ Total Score (TS) was compared inter-group using analysis of variance.
RESULTS: The analysis population (N = 158) included patients with narcolepsy (n = 49), OSP (n = 55), and controls (n = 54); mean ± SD age was 13.8 ± 2.8, 10.2 ± 4.3, and 10.0 ± 3.8 years, respectively. Inter-item Pearson correlations (range, 0.22-0.75) indicated good construct validity. Principal component analysis confirmed unidimensionality. Item discriminative power was high for narcolepsy vs control (range, 0.693-0.936) and lower for narcolepsy vs OSP (range, 0.584-0.729). The latent trait was well covered (separation index = 0.868). Item 7 (vivid dreams/nightmares), having low discriminative power and specificity, was removed. Cronbach\'s alpha (final PNSQ) indicated high internal consistency reliability (raw alpha = 0.88). Mean ± SD PNSQ TS (range, 0-50) in the narcolepsy, OSP, and control groups were 34.98 ± 7.98, 25.20 ± 9.43, and 9.54 ± 9.38, respectively (nominal P < 0.0001). Classification by PNSQ TS was defined: PNSQ+ (likely narcolepsy, TS ≥ 29), PNSQ 0 (likely OSP, TS 19-28), and PNSQ- (narcolepsy unlikely, TS ≤ 18); patients with narcolepsy were classified as PNSQ+ (79.6%), PNSQ 0 (18.4%), and PNSQ- (2.0%).
CONCLUSIONS: The PNSQ demonstrated good psychometric properties and excellent performance discriminating narcolepsy, OSP, and control groups.
METHODS: The initial PNSQ was updated following debriefing interviews with parents of children with suspected/diagnosed narcolepsy. Subsequently, newly recruited caregivers were categorized into groups: clinician-confirmed narcolepsy, other sleep problems (OSP), and no sleep problems (controls). Caregivers completed the 11-item PNSQ assessing narcolepsy symptomatology. PNSQ psychometric properties were evaluated; mean PNSQ Total Score (TS) was compared inter-group using analysis of variance.
RESULTS: The analysis population (N = 158) included patients with narcolepsy (n = 49), OSP (n = 55), and controls (n = 54); mean ± SD age was 13.8 ± 2.8, 10.2 ± 4.3, and 10.0 ± 3.8 years, respectively. Inter-item Pearson correlations (range, 0.22-0.75) indicated good construct validity. Principal component analysis confirmed unidimensionality. Item discriminative power was high for narcolepsy vs control (range, 0.693-0.936) and lower for narcolepsy vs OSP (range, 0.584-0.729). The latent trait was well covered (separation index = 0.868). Item 7 (vivid dreams/nightmares), having low discriminative power and specificity, was removed. Cronbach\'s alpha (final PNSQ) indicated high internal consistency reliability (raw alpha = 0.88). Mean ± SD PNSQ TS (range, 0-50) in the narcolepsy, OSP, and control groups were 34.98 ± 7.98, 25.20 ± 9.43, and 9.54 ± 9.38, respectively (nominal P < 0.0001). Classification by PNSQ TS was defined: PNSQ+ (likely narcolepsy, TS ≥ 29), PNSQ 0 (likely OSP, TS 19-28), and PNSQ- (narcolepsy unlikely, TS ≤ 18); patients with narcolepsy were classified as PNSQ+ (79.6%), PNSQ 0 (18.4%), and PNSQ- (2.0%).
CONCLUSIONS: The PNSQ demonstrated good psychometric properties and excellent performance discriminating narcolepsy, OSP, and control groups.
摘要：
目的：本研究评估了儿童发作性睡病筛查问卷（PNSQ）的心理测量特性，是为了应对儿童发作性睡病的识别困难而开发的。
方法：最初的PNSQ是在对疑似/诊断为发作性睡病儿童的父母进行汇报访谈后更新的。随后，新招募的护理人员被分为几组：临床医生证实的嗜睡症，其他睡眠问题（OSP）和没有睡眠问题（控制）。护理人员完成了11项PNSQ评估发作性睡病症状学。评估了PNSQ的心理测量特性；使用方差分析比较了组间的平均PNSQ总分（TS）。
结果：分析人群（N=158）包括发作性睡病患者（n=49），OSP（n=55），和对照组（n=54）；平均±SD年龄为13.8±2.8、10.2±4.3和10.0±3.8岁，分别。项目间皮尔逊相关性(范围，0.22-0.75)表示良好的结构效度。主成分分析证实了一维性。发作性睡病与对照组的项目鉴别力较高(范围，0.693-0.936)和更低的发作性睡病与OSP(范围，0.584-0.729)。潜在性状被很好地覆盖(分离指数=0.868)。项目7(生动的梦/噩梦)，具有低鉴别力和特异性，已删除。Cronbach的alpha（最终PNSQ）表明内部一致性可靠性高（原始alpha=0.88）。平均值±SDPNSQTS(范围，0-50）在发作性睡病中，OSP,对照组分别为34.98±7.98、25.20±9.43和9.54±9.38(标称P<0.0001)。根据PNSQTS定义的分类：PNSQ+(可能是发作性睡病，TS≥29),PNSQ0(可能是OSP，TS19-28)，和PNSQs-(嗜睡症不太可能，TS≤18）；发作性睡病患者分为PNSQ+（79.6%），PNSQ0（18.4%），和PNSQs-（2.0%）。
结论：PNSQ表现出良好的心理测量特性和出色的区分嗜睡症的表现，OSP,和对照组。
方法：最初的PNSQ是在对疑似/诊断为发作性睡病儿童的父母进行汇报访谈后更新的。随后，新招募的护理人员被分为几组：临床医生证实的嗜睡症，其他睡眠问题（OSP）和没有睡眠问题（控制）。护理人员完成了11项PNSQ评估发作性睡病症状学。评估了PNSQ的心理测量特性；使用方差分析比较了组间的平均PNSQ总分（TS）。
结果：分析人群（N=158）包括发作性睡病患者（n=49），OSP（n=55），和对照组（n=54）；平均±SD年龄为13.8±2.8、10.2±4.3和10.0±3.8岁，分别。项目间皮尔逊相关性(范围，0.22-0.75)表示良好的结构效度。主成分分析证实了一维性。发作性睡病与对照组的项目鉴别力较高(范围，0.693-0.936)和更低的发作性睡病与OSP(范围，0.584-0.729)。潜在性状被很好地覆盖(分离指数=0.868)。项目7(生动的梦/噩梦)，具有低鉴别力和特异性，已删除。Cronbach的alpha（最终PNSQ）表明内部一致性可靠性高（原始alpha=0.88）。平均值±SDPNSQTS(范围，0-50）在发作性睡病中，OSP,对照组分别为34.98±7.98、25.20±9.43和9.54±9.38(标称P<0.0001)。根据PNSQTS定义的分类：PNSQ+(可能是发作性睡病，TS≥29),PNSQ0(可能是OSP，TS19-28)，和PNSQs-(嗜睡症不太可能，TS≤18）；发作性睡病患者分为PNSQ+（79.6%），PNSQ0（18.4%），和PNSQs-（2.0%）。
结论：PNSQ表现出良好的心理测量特性和出色的区分嗜睡症的表现，OSP,和对照组。
