METHODS: The initial PNSQ was updated following debriefing interviews with parents of children with suspected/diagnosed narcolepsy. Subsequently, newly recruited caregivers were categorized into groups: clinician-confirmed narcolepsy, other sleep problems (OSP), and no sleep problems (controls). Caregivers completed the 11-item PNSQ assessing narcolepsy symptomatology. PNSQ psychometric properties were evaluated; mean PNSQ Total Score (TS) was compared inter-group using analysis of variance.
RESULTS: The analysis population (N = 158) included patients with narcolepsy (n = 49), OSP (n = 55), and controls (n = 54); mean ± SD age was 13.8 ± 2.8, 10.2 ± 4.3, and 10.0 ± 3.8 years, respectively. Inter-item Pearson correlations (range, 0.22-0.75) indicated good construct validity. Principal component analysis confirmed unidimensionality. Item discriminative power was high for narcolepsy vs control (range, 0.693-0.936) and lower for narcolepsy vs OSP (range, 0.584-0.729). The latent trait was well covered (separation index = 0.868). Item 7 (vivid dreams/nightmares), having low discriminative power and specificity, was removed. Cronbach\'s alpha (final PNSQ) indicated high internal consistency reliability (raw alpha = 0.88). Mean ± SD PNSQ TS (range, 0-50) in the narcolepsy, OSP, and control groups were 34.98 ± 7.98, 25.20 ± 9.43, and 9.54 ± 9.38, respectively (nominal P < 0.0001). Classification by PNSQ TS was defined: PNSQ+ (likely narcolepsy, TS ≥ 29), PNSQ 0 (likely OSP, TS 19-28), and PNSQ- (narcolepsy unlikely, TS ≤ 18); patients with narcolepsy were classified as PNSQ+ (79.6%), PNSQ 0 (18.4%), and PNSQ- (2.0%).
CONCLUSIONS: The PNSQ demonstrated good psychometric properties and excellent performance discriminating narcolepsy, OSP, and control groups.
方法:最初的PNSQ是在对疑似/诊断为发作性睡病儿童的父母进行汇报访谈后更新的。随后,新招募的护理人员被分为几组:临床医生证实的嗜睡症,其他睡眠问题(OSP)和没有睡眠问题(控制)。护理人员完成了11项PNSQ评估发作性睡病症状学。评估了PNSQ的心理测量特性;使用方差分析比较了组间的平均PNSQ总分(TS)。
结果:分析人群(N=158)包括发作性睡病患者(n=49),OSP(n=55),和对照组(n=54);平均±SD年龄为13.8±2.8、10.2±4.3和10.0±3.8岁,分别。项目间皮尔逊相关性(范围,0.22-0.75)表示良好的结构效度。主成分分析证实了一维性。发作性睡病与对照组的项目鉴别力较高(范围,0.693-0.936)和更低的发作性睡病与OSP(范围,0.584-0.729)。潜在性状被很好地覆盖(分离指数=0.868)。项目7(生动的梦/噩梦),具有低鉴别力和特异性,已删除。Cronbach的alpha(最终PNSQ)表明内部一致性可靠性高(原始alpha=0.88)。平均值±SDPNSQTS(范围,0-50)在发作性睡病中,OSP,对照组分别为34.98±7.98、25.20±9.43和9.54±9.38(标称P<0.0001)。根据PNSQTS定义的分类:PNSQ+(可能是发作性睡病,TS≥29),PNSQ0(可能是OSP,TS19-28),和PNSQs-(嗜睡症不太可能,TS≤18);发作性睡病患者分为PNSQ+(79.6%),PNSQ0(18.4%),和PNSQs-(2.0%)。
结论:PNSQ表现出良好的心理测量特性和出色的区分嗜睡症的表现,OSP,和对照组。