PDF(Pubmed)
Abstract：
Fungal infections due to Fusarium species are serious albeit rare and mostly occur in severely immunocompromised patients. The prognosis of such infections, especially of disseminated manifestations, is poor as a result of multi-antifungal resistance, particularly to azoles. We report a case of a rapidly progressive necrotizing fasciitis of the foot secondary to Fusarium solani in a young female patient with acute lymphoblastic leukemia on consolidation therapy. Surgical debridement was undertaken and liposomal amphotericin was given as definitive therapy for a total of six weeks followed by secondary prophylaxis that resulted in remarked clinical and radiological improvement. High clinical suspicion, prompt surgical intervention, rapid diagnosis, and timely initiation of appropriate antifungal therapy are crucial for a favorable outcome in this relatively uncommon life-threatening infection.
摘要：
由于镰刀菌属物种引起的真菌感染很严重，尽管很少见，并且大多数发生在严重免疫功能低下的患者中。这种感染的预后，特别是传播的表现形式，由于多种抗真菌药物的耐药性，特别是唑类。我们报道了一名接受巩固治疗的年轻女性急性淋巴细胞白血病患者继发于solani镰刀菌的足快速进行性坏死性筋膜炎的病例。进行了手术清创术，并给予脂质体两性霉素作为最终治疗，共六周，然后进行二级预防，从而显着改善了临床和放射学。临床高度怀疑,及时手术干预，快速诊断,及时开始适当的抗真菌治疗对于这种相对罕见的危及生命的感染的良好结局至关重要.
