UNASSIGNED: Relevant observational studies were obtained by searching PubMed, Embase, Cochrane\'s Library, and Web of Science databases. Study characteristics and outcome data were extracted independently by two authors. The random-effect model was used for meta-analysis considering the possible influence of between-study heterogeneity. Predefined subgroup analyses were used to evaluate the possible influences of study characteristics on the outcome.
UNASSIGNED: Eight studies involving 10,601,006 participants contributed to the meta-analysis. Results showed that MetS was independently associated with a higher risk of RCC in adult population (risk ratio [RR]: 1.62, 95% confidence interval [CI]: 1.41 to 1.87, p<0.001; I2 = 85%). Subgroup analyses showed consistent association in men (RR: 1.52, 95% CI: 1.23 to 1.89, p<0.001) and in women (RR: 1.71, 95% CI: 1.28 to 2.27, p<0.001), in Asians (RR: 1.51, 95% CI: 1.25 to 1.83, p<0.001) and in Caucasians (RR: 1.76, 95% CI: 1.46 to 2.12, p<0.001), and in community derived (RR: 1.56, 95% CI: 1.34 to 1.82, p<0.001) and non-community derived population (RR: 1.87, 95% CI: 1.71 to 2.04, p<0.001). Differences in study design or quality score also did not significantly affect the association (p for subgroup difference both >0.05).
UNASSIGNED: MetS may be independently associated with RCC in adult population.
■通过搜索PubMed,Embase,科克伦图书馆,和WebofScience数据库。研究特征和结果数据由两名作者独立提取。考虑到研究间异质性的可能影响,使用随机效应模型进行荟萃分析。使用预定义的亚组分析来评估研究特征对结果的可能影响。
■涉及10,601,006名参与者的8项研究为荟萃分析做出了贡献。结果显示,在成年人群中,MetS与较高的RCC风险独立相关(风险比[RR]:1.62,95%置信区间[CI]:1.41至1.87,p<0.001;I2=85%)。亚组分析显示,男性(RR:1.52,95%CI:1.23至1.89,p<0.001)和女性(RR:1.71,95%CI:1.28至2.27,p<0.001)的相关性一致。亚洲人(RR:1.51,95%CI:1.25至1.83,p<0.001)和高加索人(RR:1.76,95%CI:1.46至2.12,p<0.001),社区来源的(RR:1.56,95%CI:1.34至1.82,p<0.001)和非社区来源的人群(RR:1.87,95%CI:1.71至2.04,p<0.001)。研究设计或质量评分的差异也没有显着影响相关性(亚组差异均>0.05)。
■MetS可能与成年人群的RCC独立相关。