Abstract：
OBJECTIVE: To determine the 5-year incidence of primary glaucoma and its associated risk factors in rural northern China.
METHODS: Population-based cohort study. A total of 5184 participants aged 30 years and older, without glaucoma at baseline, were subjected to comprehensive standardized interviews and ophthalmic and systemic examinations at baseline and after a 5-year interval in the Handan Eye Study. Incident glaucoma was diagnosed by a consensus panel of five senior glaucoma specialists. Univariate and multivariable logistic regression analyses were performed to identify the baseline risk factors that could predict the incidence of glaucoma.
RESULTS: During the 5-year follow-up, incident primary glaucoma developed in 82 subjects (1.6%; 95% confidence interval [CI], 1.2%-1.9%). The age- and gender-standardized incidence of glaucoma among subjects ≥40 years old was 2.1% (0.4% annually), calculated according to the 2010 Chinese census. A higher age (odds ratio [OR], 1.06; 95% CI, 1.04-1.09; p < 0.001), higher intraocular pressure (IOP) (OR, 1.11; 95% CI, 1.02-1.20; p = 0.017), and vertical cup disc ratio (VCDR) ≥ 0.60 (OR, 5.30; 95% CI, 3.22-8.73; p < 0.001) were found to be associated with an increased risk of incident glaucoma. For each year, older age and each mmHg higher IOP, the risks of primary glaucoma increased by 1.2% and 2.0% per year, respectively.
CONCLUSIONS: We reported the 5-year incidence of primary glaucoma in a rural Chinese population and found that older age, higher IOP, and VCDR ≥ 0.60 at baseline could help in identifying those at highest risk of disease development.
METHODS: Population-based cohort study. A total of 5184 participants aged 30 years and older, without glaucoma at baseline, were subjected to comprehensive standardized interviews and ophthalmic and systemic examinations at baseline and after a 5-year interval in the Handan Eye Study. Incident glaucoma was diagnosed by a consensus panel of five senior glaucoma specialists. Univariate and multivariable logistic regression analyses were performed to identify the baseline risk factors that could predict the incidence of glaucoma.
RESULTS: During the 5-year follow-up, incident primary glaucoma developed in 82 subjects (1.6%; 95% confidence interval [CI], 1.2%-1.9%). The age- and gender-standardized incidence of glaucoma among subjects ≥40 years old was 2.1% (0.4% annually), calculated according to the 2010 Chinese census. A higher age (odds ratio [OR], 1.06; 95% CI, 1.04-1.09; p < 0.001), higher intraocular pressure (IOP) (OR, 1.11; 95% CI, 1.02-1.20; p = 0.017), and vertical cup disc ratio (VCDR) ≥ 0.60 (OR, 5.30; 95% CI, 3.22-8.73; p < 0.001) were found to be associated with an increased risk of incident glaucoma. For each year, older age and each mmHg higher IOP, the risks of primary glaucoma increased by 1.2% and 2.0% per year, respectively.
CONCLUSIONS: We reported the 5-year incidence of primary glaucoma in a rural Chinese population and found that older age, higher IOP, and VCDR ≥ 0.60 at baseline could help in identifying those at highest risk of disease development.
摘要：
目的：确定中国北方农村地区原发性青光眼的5年发病率及其相关危险因素。
方法：基于人群的队列研究。共有5184名30岁及以上的参与者，基线无青光眼，在邯郸眼科研究中，在基线和5年间隔后接受全面的标准化访谈以及眼科和全身检查。由五名高级青光眼专家组成的共识小组诊断了青光眼。进行了单变量和多变量逻辑回归分析，以确定可以预测青光眼发生率的基线危险因素。
结果：在5年的随访中，82名受试者发生原发性青光眼(1.6%；95%置信区间[CI]，1.2%-1.9%）。年龄≥40岁受试者中青光眼的年龄和性别标准化发生率为2.1％（每年0.4％），根据2010年中国人口普查计算。年龄较高(赔率比[OR]，1.06；95%CI，1.04-1.09；p<0.001），高眼压（IOP）（OR，1.11；95%CI，1.02-1.20；p=0.017），和垂直杯盘比率(VCDR)≥0.60(OR，5.30；95％CI，3.22-8.73；p<0.001）被发现与发生青光眼的风险增加有关。每年,年龄较大，IOP每升高mmHg，原发性青光眼的风险每年增加1.2%和2.0%，分别。
结论：我们报道了中国农村人群原发性青光眼的5年发病率，更高的IOP,基线时VCDR≥0.60有助于识别疾病发展风险最高的人群.
方法：基于人群的队列研究。共有5184名30岁及以上的参与者，基线无青光眼，在邯郸眼科研究中，在基线和5年间隔后接受全面的标准化访谈以及眼科和全身检查。由五名高级青光眼专家组成的共识小组诊断了青光眼。进行了单变量和多变量逻辑回归分析，以确定可以预测青光眼发生率的基线危险因素。
结果：在5年的随访中，82名受试者发生原发性青光眼(1.6%；95%置信区间[CI]，1.2%-1.9%）。年龄≥40岁受试者中青光眼的年龄和性别标准化发生率为2.1％（每年0.4％），根据2010年中国人口普查计算。年龄较高(赔率比[OR]，1.06；95%CI，1.04-1.09；p<0.001），高眼压（IOP）（OR，1.11；95%CI，1.02-1.20；p=0.017），和垂直杯盘比率(VCDR)≥0.60(OR，5.30；95％CI，3.22-8.73；p<0.001）被发现与发生青光眼的风险增加有关。每年,年龄较大，IOP每升高mmHg，原发性青光眼的风险每年增加1.2%和2.0%，分别。
结论：我们报道了中国农村人群原发性青光眼的5年发病率，更高的IOP,基线时VCDR≥0.60有助于识别疾病发展风险最高的人群.
