PDF(Pubmed)
Abstract：
UNASSIGNED: Although some immunocompetent patients have developed invasive aspergillosis, the vast majority of cases are seen in immunocompromised patients. COVID-19 infection has been proposed to cause immune dysfunction or suppression, which predisposes patients to fungal co-infections such as mucormycosis and aspergillosis.
UNASSIGNED: A 58-year-old woman was admitted to the hospital with confusion, dysarthria, and loss of consciousness. The patient had a 1-month prior history of severe COVID-19 infection. A computerized tomography (CT) scan and a magnetic resonance imaging (MRI) revealed an intraventricular lesion with perilesional edema and a significant midline shift, which was initially thought to be an intraventricular tumor. Following a posterior parietal craniotomy, the lesion was resected via a transcortical approach from the posterior parietal region to the right lateral ventricle. Histopathological findings confirmed intraventricular aspergillosis (IVA). The patient was treated with intravenous amphotericin B for two months and discharged with oral variconazole for 4 months.
UNASSIGNED: Covid-19 infections can result in- dissemination of fungal diseases such as aspergillosis. As a minor component of cerebral aspergillosis with a poor prognosis, intraventricular aspergillosis necessitates prompt treatment, which includes surgical resection and the administration of anti-fungal medications.
UNASSIGNED: Infection with COVID-19 causes immune dysfunction, which leads to fungal co-infection, including CNS aspergillosis. As a result, all COVID-19 patients who present with acute neurologic symptoms should have CNS aspergillosis considered in their differential diagnosis.
UNASSIGNED: A 58-year-old woman was admitted to the hospital with confusion, dysarthria, and loss of consciousness. The patient had a 1-month prior history of severe COVID-19 infection. A computerized tomography (CT) scan and a magnetic resonance imaging (MRI) revealed an intraventricular lesion with perilesional edema and a significant midline shift, which was initially thought to be an intraventricular tumor. Following a posterior parietal craniotomy, the lesion was resected via a transcortical approach from the posterior parietal region to the right lateral ventricle. Histopathological findings confirmed intraventricular aspergillosis (IVA). The patient was treated with intravenous amphotericin B for two months and discharged with oral variconazole for 4 months.
UNASSIGNED: Covid-19 infections can result in- dissemination of fungal diseases such as aspergillosis. As a minor component of cerebral aspergillosis with a poor prognosis, intraventricular aspergillosis necessitates prompt treatment, which includes surgical resection and the administration of anti-fungal medications.
UNASSIGNED: Infection with COVID-19 causes immune dysfunction, which leads to fungal co-infection, including CNS aspergillosis. As a result, all COVID-19 patients who present with acute neurologic symptoms should have CNS aspergillosis considered in their differential diagnosis.
摘要：
■尽管一些有免疫能力的患者发展为侵袭性曲霉病，绝大多数病例见于免疫功能低下的患者。有人提出COVID-19感染会导致免疫功能障碍或抑制，这使患者容易发生真菌共感染，如毛霉菌病和曲霉病。
■一名58岁的妇女因困惑入院,构音障碍,和失去知觉。该患者有1个月的严重COVID-19感染史。计算机断层扫描（CT）扫描和磁共振成像（MRI）显示脑室内病变伴有病灶周围水肿和明显的中线移位，最初被认为是脑室内肿瘤。后顶叶开颅手术后,通过经皮质入路从后顶区到右侧脑室切除病变.组织病理学结果证实了脑室内曲霉病（IVA）。患者接受静脉注射两性霉素B治疗2个月，口服雷立康唑治疗4个月。
■Covid-19感染可导致真菌疾病如曲霉病的传播。作为脑曲霉病的次要组成部分，预后不良，脑室内曲霉病需要及时治疗，其中包括手术切除和抗真菌药物的施用。
■感染COVID-19会导致免疫功能障碍，导致真菌共感染，包括中枢神经系统曲霉病。因此,所有出现急性神经系统症状的COVID-19患者在鉴别诊断时应考虑中枢神经系统曲霉病.
■一名58岁的妇女因困惑入院,构音障碍,和失去知觉。该患者有1个月的严重COVID-19感染史。计算机断层扫描（CT）扫描和磁共振成像（MRI）显示脑室内病变伴有病灶周围水肿和明显的中线移位，最初被认为是脑室内肿瘤。后顶叶开颅手术后,通过经皮质入路从后顶区到右侧脑室切除病变.组织病理学结果证实了脑室内曲霉病（IVA）。患者接受静脉注射两性霉素B治疗2个月，口服雷立康唑治疗4个月。
■Covid-19感染可导致真菌疾病如曲霉病的传播。作为脑曲霉病的次要组成部分，预后不良，脑室内曲霉病需要及时治疗，其中包括手术切除和抗真菌药物的施用。
■感染COVID-19会导致免疫功能障碍，导致真菌共感染，包括中枢神经系统曲霉病。因此,所有出现急性神经系统症状的COVID-19患者在鉴别诊断时应考虑中枢神经系统曲霉病.
