Abstract：
Anti-cytokine antibodies (ACA) are an emerging cause of acquired immunodeficiency, especially in previously healthy adults. The most frequently reported are anti-IFN-γ responsible for disseminated non-tuberculous mycobacteria infections, and anti-GM-CSF mainly in mycobacteria, cryptococcosis and nocardiosis infections. The presence of anti-IFN-α in severe COVID-19 infections has recently been described. The search for and detection of these ACAs in an unusual infection situation makes it possible to set up specific therapies in addition to the anti-infective treatment. ACAs are also frequent in various autoimmune pathologies where, in addition to being indicators of the breakdown of immune tolerance, they can modulate the activity of the disease according to their cytokine target. In this review of the literature, we will focus on the epidemiology and the clinical impact of these ACAs in healthy subjects and in infectious or dysimmune diseases.
摘要：
抗细胞因子抗体（ACA）是获得性免疫缺陷的新兴原因，尤其是以前健康的成年人。最常见的报道是导致播散性非结核分枝杆菌感染的抗IFN-γ，和抗GM-CSF主要在分枝杆菌，隐球菌病和诺卡心病感染。最近已经描述了抗IFN-α在严重的COVID-19感染中的存在。在不寻常的感染情况下搜索和检测这些ACA使得除了抗感染治疗之外还可以建立特定的治疗方法。ACA在各种自身免疫性疾病中也很常见，除了是免疫耐受能力崩溃的指标，它们可以根据其细胞因子靶标调节疾病的活性。在这篇文献综述中，我们将重点关注这些ACA在健康受试者和传染病或免疫病中的流行病学和临床影响。
