PDF(Pubmed)
Abstract：
UNASSIGNED: Although a common challenge for patients and clinicians, there is little population-level evidence on the prevalence of cardiovascular disease (CVD) in individuals diagnosed with potentially curable cancer.
UNASSIGNED: We investigated CVD rates in patients with common potentially curable malignancies and evaluated the associations between patient and disease characteristics and CVD prevalence.
UNASSIGNED: The study included cancer registry patients diagnosed in England with stage I to III breast cancer, stage I to III colon or rectal cancer, stage I to III prostate cancer, stage I to IIIA non-small-cell lung cancer, stage I to IV diffuse large B-cell lymphoma, and stage I to IV Hodgkin lymphoma from 2013 to 2018. Linked hospital records and national CVD databases were used to identify CVD. The rates of CVD were investigated according to tumor type, and associations between patient and disease characteristics and CVD prevalence were determined.
UNASSIGNED: Among the 634,240 patients included, 102,834 (16.2%) had prior CVD. Men, older patients, and those living in deprived areas had higher CVD rates. Prevalence was highest for non-small-cell lung cancer (36.1%) and lowest for breast cancer (7.7%). After adjustment for age, sex, the income domain of the Index of Multiple Deprivation, and Charlson comorbidity index, CVD remained higher in other tumor types compared to breast cancer patients.
UNASSIGNED: There is a significant overlap between cancer and CVD burden. It is essential to consider CVD when evaluating national and international treatment patterns and cancer outcomes.
UNASSIGNED: We investigated CVD rates in patients with common potentially curable malignancies and evaluated the associations between patient and disease characteristics and CVD prevalence.
UNASSIGNED: The study included cancer registry patients diagnosed in England with stage I to III breast cancer, stage I to III colon or rectal cancer, stage I to III prostate cancer, stage I to IIIA non-small-cell lung cancer, stage I to IV diffuse large B-cell lymphoma, and stage I to IV Hodgkin lymphoma from 2013 to 2018. Linked hospital records and national CVD databases were used to identify CVD. The rates of CVD were investigated according to tumor type, and associations between patient and disease characteristics and CVD prevalence were determined.
UNASSIGNED: Among the 634,240 patients included, 102,834 (16.2%) had prior CVD. Men, older patients, and those living in deprived areas had higher CVD rates. Prevalence was highest for non-small-cell lung cancer (36.1%) and lowest for breast cancer (7.7%). After adjustment for age, sex, the income domain of the Index of Multiple Deprivation, and Charlson comorbidity index, CVD remained higher in other tumor types compared to breast cancer patients.
UNASSIGNED: There is a significant overlap between cancer and CVD burden. It is essential to consider CVD when evaluating national and international treatment patterns and cancer outcomes.
摘要：
■尽管对患者和临床医生来说是一个共同的挑战，在被诊断患有潜在可治愈癌症的个体中,关于心血管疾病(CVD)患病率的人群水平证据很少.
■我们调查了患有常见潜在可治愈恶性肿瘤的患者的CVD发生率，并评估了患者与疾病特征和CVD患病率之间的关联。
■该研究包括在英格兰诊断为I至III期乳腺癌的癌症登记患者，I至III期结肠癌或直肠癌，I至III期前列腺癌,I至IIIA期非小细胞肺癌，I至IV期弥漫性大B细胞淋巴瘤,2013年至2018年I至IV期霍奇金淋巴瘤。使用关联的医院记录和国家CVD数据库来识别CVD。根据肿瘤类型调查CVD的发生率，并确定患者和疾病特征与CVD患病率之间的关联。
■在634,240名患者中，102,834（16.2％）先前有CVD。男人,老年患者,生活在贫困地区的人心血管疾病发病率较高。非小细胞肺癌的患病率最高（36.1％），乳腺癌的患病率最低（7.7％）。调整后的年龄，性别,多重剥夺指数的收入域，和Charlson合并症指数,与乳腺癌患者相比，其他肿瘤类型的CVD仍然较高。
■癌症和CVD负担之间存在显着的重叠。在评估国家和国际治疗模式和癌症结局时，必须考虑CVD。
■我们调查了患有常见潜在可治愈恶性肿瘤的患者的CVD发生率，并评估了患者与疾病特征和CVD患病率之间的关联。
■该研究包括在英格兰诊断为I至III期乳腺癌的癌症登记患者，I至III期结肠癌或直肠癌，I至III期前列腺癌,I至IIIA期非小细胞肺癌，I至IV期弥漫性大B细胞淋巴瘤,2013年至2018年I至IV期霍奇金淋巴瘤。使用关联的医院记录和国家CVD数据库来识别CVD。根据肿瘤类型调查CVD的发生率，并确定患者和疾病特征与CVD患病率之间的关联。
■在634,240名患者中，102,834（16.2％）先前有CVD。男人,老年患者,生活在贫困地区的人心血管疾病发病率较高。非小细胞肺癌的患病率最高（36.1％），乳腺癌的患病率最低（7.7％）。调整后的年龄，性别,多重剥夺指数的收入域，和Charlson合并症指数,与乳腺癌患者相比，其他肿瘤类型的CVD仍然较高。
■癌症和CVD负担之间存在显着的重叠。在评估国家和国际治疗模式和癌症结局时，必须考虑CVD。
