UNASSIGNED: In 18 patients (11 with ALMS and 7 with BBS aged 5-29) and in 42 age-matched (p < 0.05) healthy subjects, the following markers of bone turnover were assessed: serum osteocalcin (OC), osteoprotegerin (OPG), s-RANKL and urinary deoxypyridinoline - DPD. In addition, a severity of alveolar atrophy using dental panoramic radiograms was evaluated.
UNASSIGNED: Lower serum OC (p = 0.0004) and urinary DPD levels (p = 0.0056) were observed in the study group compared to controls. In ALMS and BBS patients, serum OC and urinary DPD values negatively correlated with the HOMA-IR index, while a positive correlation between the OC and 25-OHD levels and a negative correlation between s-RANKL and fasting glucose concentrations were found. A significant difference in the incidence of low-grade mandibular atrophy between patients with ALMS and BBS and controls (p < 0.0001) was observed.
UNASSIGNED: The identification of bone metabolism disorders in patients with ALMS and BBS syndromes indicates the necessity to provide them with appropriate diagnosis and treatment of these abnormalities.
■在18名患者(11名患有ALMS,7名患有BBS,年龄在5-29岁)和42名年龄匹配(p<0.05)的健康受试者中,评估了以下骨转换的标志物:血清骨钙蛋白(OC),骨保护素(OPG),s-RANKL和尿脱氧吡啶啉-DPD。此外,使用牙科全景X线照片评估牙槽萎缩的严重程度.
■与对照组相比,研究组的血清OC(p=0.0004)和尿DPD水平(p=0.0056)较低。在ALMS和BBS患者中,血清OC和尿DPD值与HOMA-IR指数呈负相关,同时发现OC和25-OHD水平呈正相关,s-RANKL与空腹血糖浓度呈负相关。观察到ALMS和BBS患者与对照组之间低度下颌骨萎缩的发生率存在显着差异(p<0.0001)。
■ALMS和BBS综合征患者骨代谢紊乱的鉴定表明有必要为他们提供这些异常的适当诊断和治疗。