PDF(Pubmed)
Abstract：
Elastin provides recoil to tissues that stretch such as the lung, blood vessels, and skin. It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over. Elastin insufficiency is seen in conditions such as Williams-Beuren syndrome and elastin-related supravalvar aortic stenosis, which are associated with a range of vascular and connective tissue manifestations. Regulation of the elastin (ELN) gene occurs at multiple levels including promoter activation/inhibition, mRNA stability, interaction with microRNAs, and alternative splicing. However, these mechanisms are incompletely understood. Better understanding of the processes controlling ELN gene expression may improve medicine\'s ability to intervene in these rare conditions, as well as to replace age-associated losses by re-initiating elastin production. This review describes what is known about the ELN gene promoter structure, transcriptional regulation by cytokines and transcription factors, and posttranscriptional regulation via mRNA stability and micro-RNA and highlights new approaches that may influence regenerative medicine.
摘要：
弹性蛋白为肺等伸展组织提供后坐力，血管,和皮肤。它在一个短暂的窗口中沉积，从产前开始，延伸到脊椎动物的青春期，然后慢慢地翻过来。弹性蛋白功能不全见于Williams-Beuren综合征和弹性蛋白相关主动脉瓣上狭窄等病症,与一系列血管和结缔组织表现有关。弹性蛋白（ELN）基因的调节发生在多个水平，包括启动子激活/抑制，mRNA稳定性，与microRNAs相互作用，和选择性拼接。然而,这些机制尚未完全理解。更好地了解控制ELN基因表达的过程可能会提高药物干预这些罕见疾病的能力，以及通过重新开始弹性蛋白生产来取代与年龄相关的损失。这篇综述描述了关于ELN基因启动子结构的已知情况，细胞因子和转录因子的转录调控，以及通过mRNA稳定性和micro-RNA进行转录后调控，并强调了可能影响再生医学的新方法。
