Abstract：
For decades, retinoids have been considered the gold standard of treatment for a variety of skin conditions.1,2 As the bioavailable form of vitamin A, retinoic acid has demonstrated the ability to reduce skin discoloration, stimulate collagen production, reduce rhytids, improve acne, and uneven skin texture.3,4 Retinoic acid is a potent drug with high bioavailability. Challenges with such a product include skin sensitivity and retinoid dermatitis.1,5 This potential irritation and discomfort may hinder patient compliance reducing visible results. The non-prescription vitamin A ingredient retinol is an effective and less irritating alternative, as it is converted into retinoic acid within the skin, causing little to no irritation when used topically. Intensive Age Refining Treatment: 0.5% pure retinol night by PCA SKIN® contains 0.5% retinol, protected and delivered into the skin with a multi-layered liposomal delivery technology. This development addresses the inherent instability of retinol,1,2,3 as well as the mitigation of irritation with the goal of enhancing patient compliance and visible results. This formulation also features niacinamide and terminalia chebula to further support the anti-aging benefits of retinol. The 12-week in vivo use of this potent, yet non-irritating retinol topical demonstrates improved patient compliance and satisfaction due to tolerability and enhanced efficacy in the improvement in overall signs of healthy skin. J Drugs Dermatol. 2022;21(7):784-788. doi:10.36849/JDD.6621.
摘要：
几十年来,类维生素A被认为是治疗各种皮肤疾病的黄金标准1,2作为维生素A的生物可利用形式,视黄酸已经证明了减少皮肤变色的能力，刺激胶原蛋白的产生，减少押韵，改善痤疮，3,4维甲酸是一种有效的药物，具有很高的生物利用度。这种产品的挑战包括皮肤敏感性和类视黄醇皮炎。这种潜在的刺激和不适可能会阻碍患者的依从性，从而减少可见的结果。非处方维生素A成分视黄醇是一种有效且刺激性较小的替代品，当它在皮肤内转化为视黄酸时，局部使用时几乎没有刺激。强化年龄精炼治疗：PCASKIN＆reg;夜间0.5％纯视黄醇包含0.5％视黄醇，用多层脂质体递送技术保护并递送到皮肤中。这一发展解决了视黄醇固有的不稳定性，1,2,3以及减轻刺激，目的是增强患者的依从性和可见的结果。该制剂还具有烟酰胺和Terminalechebula的特征，以进一步支持视黄醇的抗衰老益处。这种强效的12周体内使用，然而,无刺激性的视黄醇外用显示出改善患者依从性和满意度,这是由于耐受性和改善健康皮肤整体症状的功效增强.J药物Dermatol.2022年；21（7）：784–788。doi:10.36849/JD.6621.
