Abstract：
Osteochondral lesions of the talus (OLTs) are a common cause of post-traumatic ankle pain and disability. Atelocollagen-induced chondrogenesis (ACIC) aims to encourage the development of hyaline cartilage, which is biomechanically superior to fibrocartilage. This single-center, retrospective database study assessed patients who underwent arthroscopic microfracture with or without atelocollagen scaffold augmentation for OLT. Between 2010 and 2019, 87 patients underwent microfracture only and 31 patients underwent ACIC. Propensity score matching was used to match the ACIC group in a 1:2 ratio to a corresponding microfracture-only group using logistic regression. American Orthopaedic Foot & Ankle Society (AOFAS) scores, 100-mm Visual Analog Scale (VAS), Short Form-36 (SF-36), and satisfaction were assessed at preoperative, 3-, 6-, and 12-month intervals. There were no differences in baseline characteristics between groups after matching (P > .05). Both groups had similar improvements to VAS, AOFAS, and SF-36 scores up to 12 months (P > .05). Both groups had significant 1-year improvements to physical functioning, physical limitations in usual role activities, pain, and social functioning domains, but the ACIC group additionally had significant improvements to general health, vitality, and mental health. Patients in the ACIC group were also more satisfied than the microfracture group at all time points. Patients with OLTs who underwent ACIC reported superior satisfaction and improvements to quality of life, although clinical outcomes were similar to those who underwent microfracture alone at 1 year.Level of Evidence: Level III: Cohort study.
摘要：
距骨软骨损伤（OLTs）是创伤后踝关节疼痛和残疾的常见原因。Atelocolagen诱导的软骨形成（ACIC）旨在促进透明软骨的发育，生物力学优于纤维软骨。这个单一中心，回顾性数据库研究评估了接受关节镜下微骨折伴或不伴骨胶原支架增强的OLT患者。在2010年至2019年期间，87例患者仅接受了微骨折，31例患者接受了ACIC。倾向评分匹配用于使用逻辑回归将ACIC组以1：2的比例与相应的仅微骨折组进行匹配。美国骨科足踝协会（AOFAS）评分，100毫米视觉模拟刻度(VAS),简式36(SF-36)，和术前评估满意度，3-,6-，和12个月的间隔。匹配后组间基线特征无差异(P>.05)。两组对VAS有相似的改善，AOFAS,和SF-36得分长达12个月（P>0.05）。两组1年的身体机能都有显著改善，通常角色活动中的身体限制，疼痛,和社会功能领域，但是ACIC小组的总体健康状况也有了显着改善，活力,和心理健康。在所有时间点，ACIC组患者的满意度也高于微骨折组。接受ACIC治疗的OLT患者报告满意度高，生活质量得到改善。尽管临床结局与仅接受微骨折治疗1年的患者相似.证据水平：III级：队列研究。
