PDF(Pubmed)
Abstract：
Skin manifestations of systemic disorders give a clue to the organ involved and help identify the possible disease-causing injury. Skin changes of liver cirrhosis are not specific, as they may be seen in disorders not involving the liver. Thus, a constellation of skin changes along with systemic features may help us to identify the disease-causing liver cirrhosis. Pruritus is one of the most common and distressful symptoms of liver cirrhosis, severely affecting the quality of life, which further necessitates understanding cutaneous manifestations of cirrhosis. Other nonspecific cutaneous manifestations include spider telangiectasia, palmar erythema, paper money skin, xanthomas, pigmentation changes, nutritional deficiencies, hair changes, and nail changes. This review discusses the nonspecific skin manifestations associated with liver cirrhosis followed by specific cutaneous findings seen in common diseases causing liver cirrhosis, such as viral infections, biliary tract disorders, chronic alcoholism, and metabolic disorders. Early recognition of cutaneous features can help prevent or delay the development of complications and end-stage disease, decreasing morbidity and mortality.
摘要：
全身性疾病的皮肤表现为所涉及的器官提供了线索，并有助于确定可能的致病损伤。肝硬化的皮肤变化不是特异性的，因为它们可以在不涉及肝脏的疾病中看到。因此，一系列皮肤变化以及全身特征可能有助于我们识别引起疾病的肝硬化。瘙痒是肝硬化最常见和最痛苦的症状之一，严重影响生活质量，这进一步需要了解肝硬化的皮肤表现。其他非特异性皮肤表现包括蜘蛛毛细血管扩张症，手掌红斑,纸币皮肤，黄色瘤,色素沉着变化,营养缺乏,头发的变化,指甲的变化。这篇综述讨论了与肝硬化相关的非特异性皮肤表现，以及在导致肝硬化的常见疾病中看到的特异性皮肤表现。比如病毒感染，胆道疾病，慢性酒精中毒,和代谢紊乱。早期识别皮肤特征有助于预防或延缓并发症和终末期疾病的发展。降低发病率和死亡率。
