PDF(Pubmed)
Abstract：
To investigate if larger punctum size links to the severity of dry eye disease (DED) and perhaps, punctum size inspection can be adopted to become one of the DED evaluations for practitioners. The records of 200 eyes of 114 patients that had temporary collagen punctum plugs due to severe DED (Level 2 to Level 4) from January 1, 2017, to July 31, 2018, were reviewed for the size of the plugs. Lacrimal punctum size of those eyes was approximated according to the size of vertical canalicular soft collagen plug (from 0.3 to 0.5 mm diameter, Oasis, Lacrimedics, Glendora, CA, USA). The dry eye severity grading from the International Dry Eye WorkShop was used to grade the level of the severity of DED. Those eyes classified as Level 2 and above were considered as severe due to the presentation of moderate-to-diffuse corneal staining and symptomatic. To assess if there is a correlation between punctum size and the severity of DED, the Spearman\'s rank correlation coefficient was calculated. Of the 200 Level 2 and above eyes, 131 (66%) eyes had a large punctum (≥0.5 mm). Punctum size larger than 0.4 mm was 95%. The estimated Spearman\'s ρ was 0.16. This indicates a statistical significant positive correlation (P = 0.02) between larger punctum size and higher level of DED. The larger size of lacrimal punctum may link to the severity of DED. Punctum inspection may be adopted to become one parameter for DED evaluation for practitioners.
摘要：
为了调查较大的泪点大小是否与干眼症(DED)的严重程度相关，可通过泪点大小检查成为从业人员DED评价之一。从2017年1月1日至2018年7月31日，由于严重的DED（2级至4级）而出现临时胶原泪点塞的114例患者的200只眼的记录进行了检查，以了解插头的大小。这些眼睛的泪点大小根据垂直泪小管软胶原栓的大小(直径从0.3到0.5毫米,绿洲,泪人,Glendora,CA,美国）。使用来自国际干眼工作坊的干眼严重程度分级来对DED的严重程度进行分级。由于出现中度至弥漫性角膜染色和症状，被分类为2级及以上的那些眼睛被认为是严重的。为了评估泪点大小和DED的严重程度之间是否存在相关性，计算Spearman等级相关系数。在200个二级及以上的眼睛中，131只（66％）眼睛有大泪点（≥0.5mm）。肿块大小大于0.4mm的占95%。估计的斯皮尔曼ρ为0.16。这表明较大的泪点大小与较高的DED水平之间存在统计学上的显着正相关（P=0.02）。泪点的较大大小可能与DED的严重程度有关。Punctum检查可以成为从业人员DED评估的一个参数。
