PDF(Pubmed)
Abstract：
UNASSIGNED: Vertical mother-to-child transmission (MTCT) of the hepatitis B virus (HBV) remains an important issue. Timely administration of hepatitis B immunoglobulin (HBIG) and of the HBV vaccine is effective in preventing MTCT in infants born to HBV-infected mothers. However, HBIG is often not easily available in low-income countries or regions.
UNASSIGNED: We compared in a retrospective cohort study the HBV vaccine efficacy alone and in combination with HBIG in preventing vertical MTCT in infants born to HBeAg-negative carrier mothers in Jiangsu province, China. Based on the administration of the HBV vaccine and HBIG shortly after birth, children were divided into two groups: Group 1, administration of the HBV vaccine alone, and Group 2, concurrent use of HBIG and of the HBV vaccine.
UNASSIGNED: A total of 620 infants born to HBeAg-negative carrier mothers were enrolled into this study. Group 1 included 195 children who had received the HBV vaccine alone after birth, and Group 2, 425 children who had received both HBIG and the HBV vaccine. Children were followed up to the age of 68 and 42 months, respectively. MTCT of HBV occurred in 0% (0/195) in Group 1 (HBV vaccine alone) and 0% (0/425) in Group 2 (HBV vaccine and HBIG) (p = 1.00).
UNASSIGNED: In this retrospective cohort study, we found that HBV vaccination alone shortly after birth was effective in preventing MTCT of HBV in infants born to HBeAg-negative carrier mothers.
UNASSIGNED: We compared in a retrospective cohort study the HBV vaccine efficacy alone and in combination with HBIG in preventing vertical MTCT in infants born to HBeAg-negative carrier mothers in Jiangsu province, China. Based on the administration of the HBV vaccine and HBIG shortly after birth, children were divided into two groups: Group 1, administration of the HBV vaccine alone, and Group 2, concurrent use of HBIG and of the HBV vaccine.
UNASSIGNED: A total of 620 infants born to HBeAg-negative carrier mothers were enrolled into this study. Group 1 included 195 children who had received the HBV vaccine alone after birth, and Group 2, 425 children who had received both HBIG and the HBV vaccine. Children were followed up to the age of 68 and 42 months, respectively. MTCT of HBV occurred in 0% (0/195) in Group 1 (HBV vaccine alone) and 0% (0/425) in Group 2 (HBV vaccine and HBIG) (p = 1.00).
UNASSIGNED: In this retrospective cohort study, we found that HBV vaccination alone shortly after birth was effective in preventing MTCT of HBV in infants born to HBeAg-negative carrier mothers.
摘要：
■乙型肝炎病毒（HBV）的垂直母婴传播（MTCT）仍然是一个重要问题。及时施用乙型肝炎免疫球蛋白（HBIG）和HBV疫苗可有效预防HBV感染母亲所生的婴儿的MTCT。然而,HBIG在低收入国家或地区通常不容易获得。
■我们在一项回顾性队列研究中比较了在江苏省HBeAg阴性携带者母亲出生的婴儿中单独使用HBV疫苗和与HBIG联合使用预防垂直MTCT的疗效。中国。基于出生后不久的HBV疫苗和HBIG的管理，儿童分为两组：第1组，单独使用HBV疫苗，和第2组，同时使用HBIG和HBV疫苗。
■共有620名HBeAg阴性携带者母亲出生的婴儿参加了这项研究。第1组包括195名出生后单独接种HBV疫苗的儿童，和第2组，425名同时接受HBIG和HBV疫苗的儿童。儿童随访至68岁和42个月，分别。HBV的MTCT发生在第1组（单独的HBV疫苗）的0％（0/195）和第2组（HBV疫苗和HBIG）的0％（0/425）（p=1.00）。
■在这项回顾性队列研究中，我们发现,在HBeAg阴性携带者母亲所生的婴儿中,出生后不久单独接种HBV疫苗可有效预防HBV的MTCT.
■我们在一项回顾性队列研究中比较了在江苏省HBeAg阴性携带者母亲出生的婴儿中单独使用HBV疫苗和与HBIG联合使用预防垂直MTCT的疗效。中国。基于出生后不久的HBV疫苗和HBIG的管理，儿童分为两组：第1组，单独使用HBV疫苗，和第2组，同时使用HBIG和HBV疫苗。
■共有620名HBeAg阴性携带者母亲出生的婴儿参加了这项研究。第1组包括195名出生后单独接种HBV疫苗的儿童，和第2组，425名同时接受HBIG和HBV疫苗的儿童。儿童随访至68岁和42个月，分别。HBV的MTCT发生在第1组（单独的HBV疫苗）的0％（0/195）和第2组（HBV疫苗和HBIG）的0％（0/425）（p=1.00）。
■在这项回顾性队列研究中，我们发现,在HBeAg阴性携带者母亲所生的婴儿中,出生后不久单独接种HBV疫苗可有效预防HBV的MTCT.
