PDF(Pubmed)
Abstract：
UNASSIGNED: Optimal water intake positively affects various aspects of human physiology, especially renal function. Physical activity (PA) may have an impact on hydration status and renal health, but the interaction of hydration status and PA level on renal function is not well-studied in children.
UNASSIGNED: We conducted four waves of urine assays in our child cohort (PROC) study from October 2018 to November 2019 in Beijing, China. We measured urinary specific gravity, β2-microglobulin (β2-MG), and microalbumin (MA) excretion to assess hydration status and renal damage in the context of PA level and other covariates among 1,914 primary school children. We determined the associations of renal damage with the interaction of hydration status and PA level using generalized linear mixed-effects models.
UNASSIGNED: The prevalence of dehydration was 35.0%, 62.1%, 63.9%, and 63.3%, and the prevalence of insufficient PA was 86.2%, 44.9%, 90.4%, and 90.2% from wave 1 to wave 4 among 1,914 primary school children. From wave 1 to wave 4, the prevalence of renal tubular damage had a significant increasing trend of 8.8%, 15.9%, 25.7%, and 29.0% (Z = 16.9, P < 0.001), while the prevalence of glomerular damage revealed a declining trend of 5.6%, 5.5%, 4.4%, and 4.1% (Z = -2.4, P = 0.016). There were stable longitudinal associations of renal tubular and glomerular damage with hydration status (euhydration: OR = 0.50 and 0.33, respectively) but not with PA level. In multivariate analysis, significant interactions of hydration status and PA level were noted with renal tubular damage (β = 0.43, P = 0.014) and glomerular damage (β = 0.60, P = 0.047). Children with euhydration and insufficient PA were less likely to have renal tubular damage (OR = 0.46, 95% CI: 0.39, 0.53) or glomerular damage (OR = 0.28, 95% CI: 0.20, 0.39); children with euhydration and sufficient PA were also less likely to have renal tubular damage (OR = 0.57, 95% CI: 0.44, 0.75) or glomerular damage (OR = 0.47, 95% CI: 0.30, 0.74), adjusting for age, sex, BMI z-score, standardized SBP, sleep duration, computer/cell phone screen time, and fruit and vegetable intake.
UNASSIGNED: Children with euhydration and either sufficient or insufficient PA were less likely to have early renal damage. Adequate daily water intake for children is important, especially after PA.
UNASSIGNED: We conducted four waves of urine assays in our child cohort (PROC) study from October 2018 to November 2019 in Beijing, China. We measured urinary specific gravity, β2-microglobulin (β2-MG), and microalbumin (MA) excretion to assess hydration status and renal damage in the context of PA level and other covariates among 1,914 primary school children. We determined the associations of renal damage with the interaction of hydration status and PA level using generalized linear mixed-effects models.
UNASSIGNED: The prevalence of dehydration was 35.0%, 62.1%, 63.9%, and 63.3%, and the prevalence of insufficient PA was 86.2%, 44.9%, 90.4%, and 90.2% from wave 1 to wave 4 among 1,914 primary school children. From wave 1 to wave 4, the prevalence of renal tubular damage had a significant increasing trend of 8.8%, 15.9%, 25.7%, and 29.0% (Z = 16.9, P < 0.001), while the prevalence of glomerular damage revealed a declining trend of 5.6%, 5.5%, 4.4%, and 4.1% (Z = -2.4, P = 0.016). There were stable longitudinal associations of renal tubular and glomerular damage with hydration status (euhydration: OR = 0.50 and 0.33, respectively) but not with PA level. In multivariate analysis, significant interactions of hydration status and PA level were noted with renal tubular damage (β = 0.43, P = 0.014) and glomerular damage (β = 0.60, P = 0.047). Children with euhydration and insufficient PA were less likely to have renal tubular damage (OR = 0.46, 95% CI: 0.39, 0.53) or glomerular damage (OR = 0.28, 95% CI: 0.20, 0.39); children with euhydration and sufficient PA were also less likely to have renal tubular damage (OR = 0.57, 95% CI: 0.44, 0.75) or glomerular damage (OR = 0.47, 95% CI: 0.30, 0.74), adjusting for age, sex, BMI z-score, standardized SBP, sleep duration, computer/cell phone screen time, and fruit and vegetable intake.
UNASSIGNED: Children with euhydration and either sufficient or insufficient PA were less likely to have early renal damage. Adequate daily water intake for children is important, especially after PA.
摘要：
■最佳的水摄入量对人体生理的各个方面都有积极的影响，尤其是肾功能。身体活动（PA）可能会对水合状态和肾脏健康产生影响，但是在儿童中没有充分研究水合状态和PA水平对肾功能的相互作用。
■我们在2018年10月至2019年11月在北京的儿童队列（PROC）研究中进行了四波尿液测定，中国。我们测量了尿比重,β2-微球蛋白(β2-MG),和微量白蛋白（MA）排泄，以评估1,914名小学生中PA水平和其他协变量的水合状态和肾脏损害。我们使用广义线性混合效应模型确定了肾脏损害与水合状态和PA水平相互作用的关联。
■脱水患病率为35.0%,62.1%,63.9%,和63.3%，PA不足的患病率为86.2%，44.9%,90.4%,在1,914名小学生中，从第一波到第四波的比例为90.2%。从第1波到第4波，肾小管损害的患病率呈显著上升趋势，为8.8%，15.9%,25.7%,和29.0%（Z=16.9，P<0.001），虽然肾小球损害的患病率呈5.6%的下降趋势，5.5%,4.4%,4.1%(Z=-2.4,P=0.016)。肾小管和肾小球损伤与水合状态（正常水合：OR=0.50和0.33）之间存在稳定的纵向关联，但与PA水平无关。在多变量分析中，肾小管损伤(β=0.43,P=0.014)和肾小球损伤(β=0.60,P=0.047)与水合状态和PA水平显著交互作用。正常水化和PA不足的儿童不太可能发生肾小管损伤（OR=0.46，95％CI：0.39，0.53）或肾小球损伤（OR=0.28，95％CI：0.20，0.39）；正常水化和PA充足的儿童也不太可能发生肾小管损伤（OR=0.57，95％CI：0.44，0.75）或肾小球损伤（OR=0.47，95％CI：0.30，0.74）调整年龄，性别,BMIz评分,标准化SBP，睡眠持续时间,电脑/手机屏幕时间，水果和蔬菜的摄入量。
■水化正常且PA充足或不足的儿童早期肾损害的可能性较小。儿童每日充足的水摄入很重要，尤其是在PA之后。
■我们在2018年10月至2019年11月在北京的儿童队列（PROC）研究中进行了四波尿液测定，中国。我们测量了尿比重,β2-微球蛋白(β2-MG),和微量白蛋白（MA）排泄，以评估1,914名小学生中PA水平和其他协变量的水合状态和肾脏损害。我们使用广义线性混合效应模型确定了肾脏损害与水合状态和PA水平相互作用的关联。
■脱水患病率为35.0%,62.1%,63.9%,和63.3%，PA不足的患病率为86.2%，44.9%,90.4%,在1,914名小学生中，从第一波到第四波的比例为90.2%。从第1波到第4波，肾小管损害的患病率呈显著上升趋势，为8.8%，15.9%,25.7%,和29.0%（Z=16.9，P<0.001），虽然肾小球损害的患病率呈5.6%的下降趋势，5.5%,4.4%,4.1%(Z=-2.4,P=0.016)。肾小管和肾小球损伤与水合状态（正常水合：OR=0.50和0.33）之间存在稳定的纵向关联，但与PA水平无关。在多变量分析中，肾小管损伤(β=0.43,P=0.014)和肾小球损伤(β=0.60,P=0.047)与水合状态和PA水平显著交互作用。正常水化和PA不足的儿童不太可能发生肾小管损伤（OR=0.46，95％CI：0.39，0.53）或肾小球损伤（OR=0.28，95％CI：0.20，0.39）；正常水化和PA充足的儿童也不太可能发生肾小管损伤（OR=0.57，95％CI：0.44，0.75）或肾小球损伤（OR=0.47，95％CI：0.30，0.74）调整年龄，性别,BMIz评分,标准化SBP，睡眠持续时间,电脑/手机屏幕时间，水果和蔬菜的摄入量。
■水化正常且PA充足或不足的儿童早期肾损害的可能性较小。儿童每日充足的水摄入很重要，尤其是在PA之后。
