PDF(Pubmed)
Abstract：
UNASSIGNED: Overweight and obesity increase the risk of noncommunicable diseases (NCDs). Personalized nutrition (PN) approaches may provide tailored nutritional advice/service by focusing on individual\'s unique characteristics to prevent against NCDs.
UNASSIGNED: We aimed to compare the effect of PN intervention with the traditional \"one size fits all\" intervention on health status in overweight/obese Chinese adults.
UNASSIGNED: In this 12-week randomized controlled trial, 400 adults with BMI ≥24 kg/m2 were randomized to control group (CG, n = 200) and PN group (PNG, n = 200). The CG received conventional health guidance according to the Dietary Guidelines for Chinese Residents and Chinese DRIs Handbook, whereas the PNG experienced PN intervention that was developed by using decision trees based on the subjects\' anthropometric measurements, blood samples (phenotype), buccal cells (genotype), and dietary and physical activity (PA) assessments (baseline and updated).
UNASSIGNED: Compared with the conventional intervention, PN intervention significantly improved clinical outcomes of anthropometric (e.g., body mass index (BMI), body fat percentage, waist circumference) and blood biomarkers (e.g., blood lipids, uric acid, homocysteine). The improvement in clinical outcomes was achieved through behavior change in diet and PA. The subjects in the PNG had higher China dietary guidelines index values and PA levels. Personalized recommendations of \"lose weight,\" \"increase fiber\" and \"take multivitamin/mineral supplements\" were the major contributors to the decrease of BMI and improvement of lipid profile.
UNASSIGNED: We provided the first evidence that PN intervention was more beneficial than conventional nutrition intervention to improve health status in overweight/obese Chinese adults. This study provides a model of framework for developing personalized advice in Chinese population.Chictr.org.cn (ChiCTR1900026226).
UNASSIGNED: We aimed to compare the effect of PN intervention with the traditional \"one size fits all\" intervention on health status in overweight/obese Chinese adults.
UNASSIGNED: In this 12-week randomized controlled trial, 400 adults with BMI ≥24 kg/m2 were randomized to control group (CG, n = 200) and PN group (PNG, n = 200). The CG received conventional health guidance according to the Dietary Guidelines for Chinese Residents and Chinese DRIs Handbook, whereas the PNG experienced PN intervention that was developed by using decision trees based on the subjects\' anthropometric measurements, blood samples (phenotype), buccal cells (genotype), and dietary and physical activity (PA) assessments (baseline and updated).
UNASSIGNED: Compared with the conventional intervention, PN intervention significantly improved clinical outcomes of anthropometric (e.g., body mass index (BMI), body fat percentage, waist circumference) and blood biomarkers (e.g., blood lipids, uric acid, homocysteine). The improvement in clinical outcomes was achieved through behavior change in diet and PA. The subjects in the PNG had higher China dietary guidelines index values and PA levels. Personalized recommendations of \"lose weight,\" \"increase fiber\" and \"take multivitamin/mineral supplements\" were the major contributors to the decrease of BMI and improvement of lipid profile.
UNASSIGNED: We provided the first evidence that PN intervention was more beneficial than conventional nutrition intervention to improve health status in overweight/obese Chinese adults. This study provides a model of framework for developing personalized advice in Chinese population.Chictr.org.cn (ChiCTR1900026226).
摘要：
超重和肥胖会增加非传染性疾病（NCDs）的风险。个性化营养（PN）方法可以通过关注个人的独特特征来预防非传染性疾病，从而提供量身定制的营养建议/服务。
■我们旨在比较PN干预与传统的“一刀切”干预对超重/肥胖中国成年人健康状况的影响。
■在这项为期12周的随机对照试验中，400名BMI≥24kg/m2的成年人随机分为对照组(CG，n=200)和PN组(PNG，n=200)。CG根据《中国居民膳食指南》和《中国DRIs手册》接受常规健康指导，而PNG经历的PN干预是通过使用基于受试者人体测量的决策树而开发的，血液样本（表型），口腔细胞（基因型），和饮食和体力活动（PA）评估（基线和更新）。
■与常规干预相比，PN干预显著改善了人体测量的临床结果(例如，体重指数（BMI），身体脂肪百分比，腰围)和血液生物标志物(例如，血脂,尿酸,同型半胱氨酸）。临床结果的改善是通过饮食和PA的行为改变来实现的。PNG中的受试者具有较高的中国膳食指南指数值和PA水平。“减肥”的个性化建议，“增加纤维”和“服用多种维生素/矿物质补充剂”是降低BMI和改善血脂状况的主要原因。
■我们提供了第一个证据，证明PN干预比常规营养干预更有利于改善超重/肥胖中国成年人的健康状况。本研究为在中国人群中开发个性化建议提供了一个框架模型。Chictr.org.cn(ChiCTR1900026226)。
■我们旨在比较PN干预与传统的“一刀切”干预对超重/肥胖中国成年人健康状况的影响。
■在这项为期12周的随机对照试验中，400名BMI≥24kg/m2的成年人随机分为对照组(CG，n=200)和PN组(PNG，n=200)。CG根据《中国居民膳食指南》和《中国DRIs手册》接受常规健康指导，而PNG经历的PN干预是通过使用基于受试者人体测量的决策树而开发的，血液样本（表型），口腔细胞（基因型），和饮食和体力活动（PA）评估（基线和更新）。
■与常规干预相比，PN干预显著改善了人体测量的临床结果(例如，体重指数（BMI），身体脂肪百分比，腰围)和血液生物标志物(例如，血脂,尿酸,同型半胱氨酸）。临床结果的改善是通过饮食和PA的行为改变来实现的。PNG中的受试者具有较高的中国膳食指南指数值和PA水平。“减肥”的个性化建议，“增加纤维”和“服用多种维生素/矿物质补充剂”是降低BMI和改善血脂状况的主要原因。
■我们提供了第一个证据，证明PN干预比常规营养干预更有利于改善超重/肥胖中国成年人的健康状况。本研究为在中国人群中开发个性化建议提供了一个框架模型。Chictr.org.cn(ChiCTR1900026226)。
