Abstract：
BACKGROUND: Multiple sclerosis (MS) is characterized by progressive demyelinating deterioration of nervous tissues in the brain and cord, leading to a disruption in the ability of parts of the nervous system to transmit signals. Although dorsal column pathways are compromised in neuropathological studies, gait control assessments, especially on speed effects, have been understudied in MS.
OBJECTIVE: This study aimed to compare bilateral coordination of gait in subjects with MS at self-selected and fast speed and to relate these findings to disease severity (Expanded Disability Status Scale (EDSS)) and age.
METHODS: An age-matched and sex-matched case-control study was performed to assess the bilateral coordination of gait of 26 MS subjects by evaluating the gait spatiotemporal parameters captured by an inertial measurement unit sensor. The bilateral variability, accuracy, and overall coordination (the sum of variability and accuracy) were assessed at a self-selected and fast speed, and correlated with disease severity and age.
RESULTS: All gait control parameters improved at the fast speed compared to the self-selected walking speed (p<0.05 for all comparisons). The bilateral coordination of gait was moderately related to disease severity and age (p<0.05), and the gait spatiotemporal parameters were related to disease severity (p<0.001, from R=0.66 to R=0.70).
CONCLUSIONS: Patients with MS showed significant impairment in the bilateral coordination of gait at self-selected compared to fast speed. Functional mobility tests and locomotor interventions should be cautious when analyzed at different paces. Interventions aiming to increase speed can be a proper and safe strategy in locomotor studies.
OBJECTIVE: This study aimed to compare bilateral coordination of gait in subjects with MS at self-selected and fast speed and to relate these findings to disease severity (Expanded Disability Status Scale (EDSS)) and age.
METHODS: An age-matched and sex-matched case-control study was performed to assess the bilateral coordination of gait of 26 MS subjects by evaluating the gait spatiotemporal parameters captured by an inertial measurement unit sensor. The bilateral variability, accuracy, and overall coordination (the sum of variability and accuracy) were assessed at a self-selected and fast speed, and correlated with disease severity and age.
RESULTS: All gait control parameters improved at the fast speed compared to the self-selected walking speed (p<0.05 for all comparisons). The bilateral coordination of gait was moderately related to disease severity and age (p<0.05), and the gait spatiotemporal parameters were related to disease severity (p<0.001, from R=0.66 to R=0.70).
CONCLUSIONS: Patients with MS showed significant impairment in the bilateral coordination of gait at self-selected compared to fast speed. Functional mobility tests and locomotor interventions should be cautious when analyzed at different paces. Interventions aiming to increase speed can be a proper and safe strategy in locomotor studies.
摘要：
背景：多发性硬化症（MS）的特征是大脑和脊髓中神经组织的进行性脱髓鞘恶化，导致神经系统部分传输信号的能力中断。尽管在神经病理学研究中背柱通路受损，步态控制评估，尤其是速度效应,在女士中研究不足。
目的：本研究旨在比较MS患者自我选择和快速步态的双侧协调性，并将这些发现与疾病严重程度（扩展残疾状态量表（EDSS））和年龄相关。
方法：进行了年龄匹配和性别匹配的病例对照研究，以通过评估由惯性测量单元传感器捕获的步态时空参数来评估26名MS受试者的步态的双侧协调性。双侧变异性，准确度,和整体协调（可变性和准确性的总和）以自我选择和快速的速度进行评估，并与疾病严重程度和年龄相关。
结果：与自选择的步行速度相比，所有步态控制参数在较快的速度下都得到了改善（对于所有比较，p<0.05）。步态的双侧协调性与疾病严重程度和年龄中度相关(p<0.05),步态时空参数与疾病严重程度相关（从R=0.66到R=0.70，p<0.001）。
结论：与快速相比，MS患者在自我选择时步态的双侧协调性明显受损。在不同的速度进行分析时，应谨慎进行功能移动性测试和运动干预。在运动研究中，旨在提高速度的干预措施可能是一种适当且安全的策略。
目的：本研究旨在比较MS患者自我选择和快速步态的双侧协调性，并将这些发现与疾病严重程度（扩展残疾状态量表（EDSS））和年龄相关。
方法：进行了年龄匹配和性别匹配的病例对照研究，以通过评估由惯性测量单元传感器捕获的步态时空参数来评估26名MS受试者的步态的双侧协调性。双侧变异性，准确度,和整体协调（可变性和准确性的总和）以自我选择和快速的速度进行评估，并与疾病严重程度和年龄相关。
结果：与自选择的步行速度相比，所有步态控制参数在较快的速度下都得到了改善（对于所有比较，p<0.05）。步态的双侧协调性与疾病严重程度和年龄中度相关(p<0.05),步态时空参数与疾病严重程度相关（从R=0.66到R=0.70，p<0.001）。
结论：与快速相比，MS患者在自我选择时步态的双侧协调性明显受损。在不同的速度进行分析时，应谨慎进行功能移动性测试和运动干预。在运动研究中，旨在提高速度的干预措施可能是一种适当且安全的策略。
