Abstract：
OBJECTIVE: To develop a predictable and reproducible model of knee osteoarthritis after medial meniscus posterior root release.
METHODS: Posteromedial meniscal root tears were created in 12 White New Zealand rabbit knees. The contralateral limbs were used as healthy controls. The animals were euthanized at 16 weeks postoperatively; tissue samples of femoral and tibial articular cartilage were collected and processed for macro and microscopic analyses to detect signs of early degeneration. Clinical evaluation of the weight-bearing status on the affected knee was conducted at 0-, 4-, 8-, and 16-weeks postoperatively.
RESULTS: Early and severe osteoarthritic changes were the hallmark and the main findings after 16-weeks post-surgery. Macroscopically, extensive osteoarthritic changes were observed across the femoral condyle and tibial plateau. Microscopic finding included ulcerations, fissures, fibrillations, pitting, and loss of the superficial layer. Cellularity was diminished, the normal pattern of distribution in columns was lost, and subchondral bone exposure was also evident.
CONCLUSIONS: This study describes a novel model of knee osteoarthritis that may guide the development of tailored interventions to delay or prevent knee osteoarthritis. This knowledge could shift the current treatment paradigm toward more conservative and knee salvageable treatment options and increase surgeons\' awareness of this injury pattern. Such considerations may have a positive impact on clinical decision-making and subsequent patient-reported clinical outcomes.
METHODS: Controlled laboratory study.
METHODS: II.
METHODS: Posteromedial meniscal root tears were created in 12 White New Zealand rabbit knees. The contralateral limbs were used as healthy controls. The animals were euthanized at 16 weeks postoperatively; tissue samples of femoral and tibial articular cartilage were collected and processed for macro and microscopic analyses to detect signs of early degeneration. Clinical evaluation of the weight-bearing status on the affected knee was conducted at 0-, 4-, 8-, and 16-weeks postoperatively.
RESULTS: Early and severe osteoarthritic changes were the hallmark and the main findings after 16-weeks post-surgery. Macroscopically, extensive osteoarthritic changes were observed across the femoral condyle and tibial plateau. Microscopic finding included ulcerations, fissures, fibrillations, pitting, and loss of the superficial layer. Cellularity was diminished, the normal pattern of distribution in columns was lost, and subchondral bone exposure was also evident.
CONCLUSIONS: This study describes a novel model of knee osteoarthritis that may guide the development of tailored interventions to delay or prevent knee osteoarthritis. This knowledge could shift the current treatment paradigm toward more conservative and knee salvageable treatment options and increase surgeons\' awareness of this injury pattern. Such considerations may have a positive impact on clinical decision-making and subsequent patient-reported clinical outcomes.
METHODS: Controlled laboratory study.
METHODS: II.
摘要：
目的：开发一种可预测且可重复的内侧半月板后根松解术后膝骨关节炎模型。
方法：在12只新西兰白兔膝盖中产生后内侧半月板根撕裂。对侧肢体用作健康对照。在术后16周时将动物安乐死;收集股骨和胫骨关节软骨的组织样品并处理用于宏观和微观分析以检测早期变性的迹象。在0-，4-,8-,术后16周。
结果：早期和严重的骨关节炎改变是术后16周的标志和主要发现。宏观上,在股骨髁和胫骨平台上观察到广泛的骨关节炎改变。显微镜发现包括溃疡，裂缝,纤颤,点蚀,和表层的损失。细胞减少了,列中的正态分布丢失了，软骨下骨暴露也很明显。
结论：这项研究描述了一种新型的膝骨关节炎模型，该模型可以指导开发定制的干预措施以延迟或预防膝骨关节炎。这些知识可以将当前的治疗模式转向更保守和膝盖可挽救的治疗选择，并增加外科医生对这种损伤模式的认识。这些考虑因素可能对临床决策和随后的患者报告的临床结果产生积极影响。
方法：对照实验室研究。
方法：II.
方法：在12只新西兰白兔膝盖中产生后内侧半月板根撕裂。对侧肢体用作健康对照。在术后16周时将动物安乐死;收集股骨和胫骨关节软骨的组织样品并处理用于宏观和微观分析以检测早期变性的迹象。在0-，4-,8-,术后16周。
结果：早期和严重的骨关节炎改变是术后16周的标志和主要发现。宏观上,在股骨髁和胫骨平台上观察到广泛的骨关节炎改变。显微镜发现包括溃疡，裂缝,纤颤,点蚀,和表层的损失。细胞减少了,列中的正态分布丢失了，软骨下骨暴露也很明显。
结论：这项研究描述了一种新型的膝骨关节炎模型，该模型可以指导开发定制的干预措施以延迟或预防膝骨关节炎。这些知识可以将当前的治疗模式转向更保守和膝盖可挽救的治疗选择，并增加外科医生对这种损伤模式的认识。这些考虑因素可能对临床决策和随后的患者报告的临床结果产生积极影响。
方法：对照实验室研究。
方法：II.
