Abstract：
BACKGROUND: During the treatment of diseases, histone deacetylases (HDAC) may have side effects such as strong immune inhibition and drug resistance, which may lead to damage of heart, liver and kidney. Traditional Chinese medicine (TCM) is a valuable and unique resource in China, which has good efficacy and safety. At present, it has been found that Chinese herbal compounds and active ingredients can effectively inhibit the expression of HDAC. Moreover, pharmacological studies have shown that these TCMs have shown therapeutic effects in the treatment of cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases and skin diseases.
OBJECTIVE: This article reviews the mechanism of action of HDAC, and introduces the epigenetic correlation between TCM and HDAC. We expounded the histone deacetylase inhibitor (HDACi)-like inhibitory effect and clinical application of natural drugs, and summarized the research progress of TCM on HDAC in recent years.
METHODS: We collected relevant information published before March 2022 by searching the literature in various online databases such as PubMed, CNKI, Wanfang Database, Elsevier, Web of Science and China Biomedical Database. Search terms include \"HDAC\" or \"HDACi\", as well as \"herb\" or \"herbal ingredient\".
RESULTS: A large number of studies have proved that many TCMs and their chemical components have the effect of inhibiting HDAC activity, which is highly selective, acts on different HDAC subtypes, and plays a certain therapeutic effect in cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases, skin diseases and other diseases by inhibiting the process of HDAC.
CONCLUSIONS: The review of this paper is helpful to understand and excavate the active components of TCM, further explore the role of plant drugs with HDACi-like effect in diseases, and provide ideas for the development of new HDACi.
OBJECTIVE: This article reviews the mechanism of action of HDAC, and introduces the epigenetic correlation between TCM and HDAC. We expounded the histone deacetylase inhibitor (HDACi)-like inhibitory effect and clinical application of natural drugs, and summarized the research progress of TCM on HDAC in recent years.
METHODS: We collected relevant information published before March 2022 by searching the literature in various online databases such as PubMed, CNKI, Wanfang Database, Elsevier, Web of Science and China Biomedical Database. Search terms include \"HDAC\" or \"HDACi\", as well as \"herb\" or \"herbal ingredient\".
RESULTS: A large number of studies have proved that many TCMs and their chemical components have the effect of inhibiting HDAC activity, which is highly selective, acts on different HDAC subtypes, and plays a certain therapeutic effect in cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases, skin diseases and other diseases by inhibiting the process of HDAC.
CONCLUSIONS: The review of this paper is helpful to understand and excavate the active components of TCM, further explore the role of plant drugs with HDACi-like effect in diseases, and provide ideas for the development of new HDACi.
摘要：
背景：在治疗疾病的过程中，组蛋白去乙酰化酶(HDAC)可能具有强烈的免疫抑制和耐药等副作用,这可能会导致心脏受损，肝脏和肾脏。中药是我国宝贵而独特的资源,具有良好的疗效和安全性。目前,研究发现,中草药化合物和活性成分能有效抑制HDAC的表达。此外，药理学研究表明，这些中药在治疗癌症方面显示出治疗作用，心脑血管疾病,骨科疾病和皮肤病。
目的：本文综述了HDAC的作用机制,并介绍了中医药与HDAC的表观遗传相关性。阐述了组蛋白去乙酰化酶抑制剂(HDACi)类天然药物的抑制作用及临床应用,综述了近年来中医药在HDAC方面的研究进展。
方法：我们通过在各种在线数据库（如PubMed、CNKI,万方数据库,Elsevier,WebofScience和中国生物医学数据库。搜索词包括\"HDAC\"或\"HDACi\",以及“草药”或“草药成分”。
结果：大量研究证明，许多TCM及其化学成分具有抑制HDAC活性的作用，这是高度选择性的，作用于不同的HDAC亚型，对癌症有一定的治疗作用，心脑血管疾病,骨科疾病,皮肤病和其他疾病通过抑制HDAC的过程。
结论:本文的综述有助于理解和挖掘中药的有效成分,进一步探讨具有HDACi样效应的植物药在疾病中的作用，并为新型HDACi的开发提供思路。
目的：本文综述了HDAC的作用机制,并介绍了中医药与HDAC的表观遗传相关性。阐述了组蛋白去乙酰化酶抑制剂(HDACi)类天然药物的抑制作用及临床应用,综述了近年来中医药在HDAC方面的研究进展。
方法：我们通过在各种在线数据库（如PubMed、CNKI,万方数据库,Elsevier,WebofScience和中国生物医学数据库。搜索词包括\"HDAC\"或\"HDACi\",以及“草药”或“草药成分”。
结果：大量研究证明，许多TCM及其化学成分具有抑制HDAC活性的作用，这是高度选择性的，作用于不同的HDAC亚型，对癌症有一定的治疗作用，心脑血管疾病,骨科疾病,皮肤病和其他疾病通过抑制HDAC的过程。
结论:本文的综述有助于理解和挖掘中药的有效成分,进一步探讨具有HDACi样效应的植物药在疾病中的作用，并为新型HDACi的开发提供思路。
