Abstract：
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing flavonoids have been widely used in traditional medicine for thousands of years. Flavonols present in our diet may prevent cancer initiation, promotion and progression by modulating important enzymes and receptors in signal transduction pathways related to proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis and reversal of multidrug resistance. The anticancer activity of fisetin has been widely documented in numerous in vitro and in vivo studies. This review summarizes the worldwide, evidence-based research on the activity of fisetin toward various types of cancerous conditions, while describing the chemopreventive and therapeutic effects, molecular targets and mechanisms that contribute to the observed anticancer activity of fisetin. In addition, this review synthesized the results from preclinical studies on the use of fisetin as an anticancer agent. Based on the available literature, it might be suggested that fisetin has a bioactive potential to become a complementary drug in the prevention and treatment of cancerous conditions. However, more in-depth research is required to validate current data, so that this compound or its derivatives can enter the clinical trial phase.
摘要：
饮食在维持体内平衡中起着至关重要的作用。含有黄酮类化合物的植物和香料在传统医学中已广泛使用了数千年。我们饮食中存在的黄酮醇可以预防癌症的发生，通过调节与增殖相关的信号转导途径中的重要酶和受体来促进和发展，分化,凋亡，炎症,血管生成,转移和多药耐药逆转。在许多体外和体内研究中已广泛记录了非塞素的抗癌活性。这篇综述总结了世界范围内的情况，基于证据的非塞汀对各种类型的癌症疾病的活性研究，在描述化学预防和治疗效果时，分子靶标和机制有助于观察到的非瑟酮的抗癌活性。此外,这篇综述综合了非塞汀作为抗癌药物的临床前研究结果。根据现有文献，这可能表明，非塞汀具有生物活性潜力，可以成为预防和治疗癌症的补充药物。然而,需要更深入的研究来验证当前的数据，以便该化合物或其衍生物可以进入临床试验阶段。
