Abstract：
Inflammatory diseases of the skin, including atopic dermatitis and psoriasis, have gained increasing attention with rising incidences in developed countries over the past decades. While bodily properties, such as immunological responses of the skin, have been described in some detail, interactions with the brain via different routes are less well studied. The suggested routes of the skin-brain axis comprise the immune system, HPA axis, and the peripheral and central nervous system, including microglia responses and structural changes. They provide starting points to investigate the molecular mechanisms of neuropsychiatric comorbidities in AD and psoriasis. To this end, mouse models exist for AD and psoriasis that could be tested for relevant behavioral entities. In this review, we provide an overview of the current mouse models and assays. By combining an extensive behavioral characterization and state-of-the-art genetic interventions with the investigation of underlying molecular pathways, insights into the mechanisms of the skin-brain axis in inflammatory cutaneous diseases are examined, which will spark further research in humans and drive the development of novel therapeutic strategies.
摘要：
皮肤炎症性疾病，包括特应性皮炎和牛皮癣，在过去的几十年里，随着发达国家发病率的上升，人们越来越关注。虽然身体属性，比如皮肤的免疫反应，已经详细描述了，通过不同途径与大脑的相互作用研究较少。皮肤-脑轴的建议路径包括免疫系统，HPA轴,以及周围和中枢神经系统，包括小胶质细胞反应和结构变化。它们为研究AD和牛皮癣中神经精神合并症的分子机制提供了起点。为此,存在AD和牛皮癣的小鼠模型，可以测试相关行为实体。在这次审查中,我们提供了当前小鼠模型和试验的概述。通过将广泛的行为表征和最先进的遗传干预与潜在分子途径的研究相结合，对炎症性皮肤病中皮肤-脑轴的机制进行了研究，这将引发人类的进一步研究，并推动新的治疗策略的发展。
