Abstract：
Neutrophils are the most abundant leukocytes in humans and are critical for innate immunity and inflammation. Integrins are critical for neutrophil functions, especially for their recruitment to sites of inflammation or infections. Integrin conformational changes during activation have been heavily investigated but are still not fully understood. Many regulators, such as talin, Rap1-interacting adaptor molecule (RIAM), Rap1, and kindlin, are critical for integrin activation and might be potential targets for integrin-regulating drugs in treating inflammatory diseases. In this review, we outline integrin activation regulators in neutrophils with a focus on the above critical regulators, as well as newly discovered modulators that are involved in integrin activation.
摘要：
中性粒细胞是人类中最丰富的白细胞，对先天免疫和炎症至关重要。整合素对中性粒细胞功能至关重要，特别是他们招募到炎症或感染部位。已经对活化过程中的整合素构象变化进行了大量研究，但仍未完全了解。许多监管机构，比如塔林，Rap1相互作用衔接分子（RIAM），Rap1和kindlin，对于整合素激活至关重要，并且可能是整合素调节药物治疗炎症性疾病的潜在靶标。在这次审查中,我们概述了中性粒细胞中整合素激活调节剂，重点是上述关键调节剂，以及新发现的参与整合素激活的调节剂。
