Abstract：
BACKGROUND: A third follow-up study, mean 40.7 years after uveitis onset, of a cohort originally consisting of 55 Swedish patients with uveitis associated with juvenile arthritis.
METHODS: A retrospective study of the patients\' ophthalmic medical records. The results were compared to those of the same cohort previously studied at mean 7.2 and 24.0 years after uveitis onset. In the present follow-up study, 30 of the original 55 patients consented to participate. Of these, 26 had ophthalmic medical records that were reviewed.
RESULTS: In the 30 participants, active uveitis was seen in 43.4%, cataracts in 66.6% and glaucoma in 40.0%. When comparing data from previous follow-ups of the same cohort, a total of 61.8% were reported to have had cataracts at any of the three follow-ups, 29.0% had glaucoma or ocular hypertension and 12.7% had severe visual impairment in both eyes. At mean 40.7 years after uveitis onset 20% of patients in the original uveitis cohort were deceased. In 4 of the 11 deceased individuals, rheumatic disease was stated as the main cause of death, and in 3 it was considered a contributory factor in the patients deaths.
CONCLUSIONS: Uveitis associated with juvenile arthritis can be active into midlife and possibly longer. Ocular complications and visual loss increased up to 40 years after uveitis diagnosis. The mortality rate of this cohort was higher than that of a corresponding Swedish population. Lifelong ophthalmic check-ups are probably necessary for patients diagnosed with this type of uveitis.
METHODS: A retrospective study of the patients\' ophthalmic medical records. The results were compared to those of the same cohort previously studied at mean 7.2 and 24.0 years after uveitis onset. In the present follow-up study, 30 of the original 55 patients consented to participate. Of these, 26 had ophthalmic medical records that were reviewed.
RESULTS: In the 30 participants, active uveitis was seen in 43.4%, cataracts in 66.6% and glaucoma in 40.0%. When comparing data from previous follow-ups of the same cohort, a total of 61.8% were reported to have had cataracts at any of the three follow-ups, 29.0% had glaucoma or ocular hypertension and 12.7% had severe visual impairment in both eyes. At mean 40.7 years after uveitis onset 20% of patients in the original uveitis cohort were deceased. In 4 of the 11 deceased individuals, rheumatic disease was stated as the main cause of death, and in 3 it was considered a contributory factor in the patients deaths.
CONCLUSIONS: Uveitis associated with juvenile arthritis can be active into midlife and possibly longer. Ocular complications and visual loss increased up to 40 years after uveitis diagnosis. The mortality rate of this cohort was higher than that of a corresponding Swedish population. Lifelong ophthalmic check-ups are probably necessary for patients diagnosed with this type of uveitis.
摘要：
背景：第三次随访研究，葡萄膜炎发病后平均40.7年，最初由55名瑞典葡萄膜炎与幼年关节炎相关的患者组成的队列。
方法：对患者眼科病历的回顾性研究。将结果与先前在葡萄膜炎发作后平均7.2年和24.0年研究的相同队列的结果进行比较。在目前的后续研究中，最初的55名患者中有30名同意参加。其中,26人的眼科医疗记录被审查。
结果：在30名参与者中，活动期葡萄膜炎占43.4%,白内障占66.6%，青光眼占40.0%。当比较同一队列先前随访的数据时，报告共有61.8%的人在三次随访中的任何一次患有白内障，29.0％患有青光眼或高眼压，而12.7％的双眼患有严重的视力障碍。葡萄膜炎发病后平均40.7年，原始葡萄膜炎队列中有20％的患者死亡。11名死者中有4名,风湿性疾病被认为是死亡的主要原因，在3中，它被认为是患者死亡的一个促成因素。
结论：与幼年关节炎相关的葡萄膜炎可以活跃到中年甚至更长。眼并发症和视力丧失增加到葡萄膜炎诊断后40年。该队列的死亡率高于相应的瑞典人口。对于诊断为这种类型的葡萄膜炎的患者，终身眼科检查可能是必要的。
方法：对患者眼科病历的回顾性研究。将结果与先前在葡萄膜炎发作后平均7.2年和24.0年研究的相同队列的结果进行比较。在目前的后续研究中，最初的55名患者中有30名同意参加。其中,26人的眼科医疗记录被审查。
结果：在30名参与者中，活动期葡萄膜炎占43.4%,白内障占66.6%，青光眼占40.0%。当比较同一队列先前随访的数据时，报告共有61.8%的人在三次随访中的任何一次患有白内障，29.0％患有青光眼或高眼压，而12.7％的双眼患有严重的视力障碍。葡萄膜炎发病后平均40.7年，原始葡萄膜炎队列中有20％的患者死亡。11名死者中有4名,风湿性疾病被认为是死亡的主要原因，在3中，它被认为是患者死亡的一个促成因素。
结论：与幼年关节炎相关的葡萄膜炎可以活跃到中年甚至更长。眼并发症和视力丧失增加到葡萄膜炎诊断后40年。该队列的死亡率高于相应的瑞典人口。对于诊断为这种类型的葡萄膜炎的患者，终身眼科检查可能是必要的。
