PDF(Pubmed)
Abstract：
The association between malignancies and autoimmunity had been well-established. The proposed pathophysiology and causality can be bidirectional. For example, a paraneoplastic syndrome can be triggered by an underlying malignancy or vice versa, where chronic inflammation of organs affected by autoimmunity can induce malignant transformation such as the case with inflammatory bowel disease and colorectal cancer or primary sclerosing cholangitis and hepatobiliary cancer. This report presents a case of autoimmune phenomena, namely, autoimmune hemolytic anemia, pernicious anemia, and Graves disease associated with newly diagnosed breast cancer. We also highlight the postulated pathophysiologic mechanisms in an attempt to answer the question of whether the occurrence of these autoimmune phenomena in our patient is a result of the law of parsimony (Occam\'s razor), where clinical variables are pathogenically related, or the counterargument, where random events and diseases can take place simultaneously (Hickam\'s dictum).
摘要：
恶性肿瘤和自身免疫之间的关联已经很好地确定。所提出的病理生理学和因果关系可以是双向的。例如,副肿瘤综合征可以由潜在的恶性肿瘤引发，反之亦然，其中受自身免疫影响的器官的慢性炎症可以诱导恶性转化，例如炎症性肠病和结直肠癌或原发性硬化性胆管炎和肝胆癌。本报告介绍了一个自身免疫现象的案例，即,自身免疫性溶血性贫血,恶性贫血,和与新诊断的乳腺癌相关的Graves病。我们还强调了假定的病理生理机制，以试图回答以下问题：我们患者中这些自身免疫现象的发生是否是简约定律的结果（奥卡姆剃刀），临床变量与病因相关，或者相反的论点，随机事件和疾病可以同时发生(希卡姆的格言)。
