PDF(Pubmed)
Abstract：
UNASSIGNED: Although much of the research on the plausible environmental triggers for inflammatory bowel disease (IBD) has focused on bacterial pathogens, the relationship between bowel colonization with human papillomavirus (HPV) and IBD has not been previously explored. In this study, we aimed to investigate the association between HPV ileocolonic colonization and IBD.
UNASSIGNED: We performed a cross-sectional study involving consecutive patients with established IBD who were referred for endoscopic evaluation. During endoscopy, mucosal biopsies were obtained from the most inflamed colonic or ileal segments in cases and from the rectosigmoid region for controls. A hybrid capture assay was used to detect tissue HPV. The prevalence of HPV colonization was determined for cases and controls and was compared using Fisher\'s exact test.
UNASSIGNED: A total of 201 patients, including 104 patients with IBD and 97 non-IBD controls, were prospectively included. Females comprised 55.5% of the study participants (58% vs. 55.2% for controls, P = 0.94). Fifty-seven (54.8%) patients had ulcerative colitis, and 45 (43.2%) had Crohn\'s disease. The mean age was 43.2 +-18.2 years. Endoscopically active disease was documented in 56 cases (56%). HPV colonization was detected in four (4.1% subjects in controls vs. none in the cases, P = 0.05).
UNASSIGNED: There was no evidence of HPV ileocolonic colonization in this cohort of patients with IBD, regardless of disease activity. HPV colonization does not appear to be linked to IBD diagnosis or disease severity.
UNASSIGNED: We performed a cross-sectional study involving consecutive patients with established IBD who were referred for endoscopic evaluation. During endoscopy, mucosal biopsies were obtained from the most inflamed colonic or ileal segments in cases and from the rectosigmoid region for controls. A hybrid capture assay was used to detect tissue HPV. The prevalence of HPV colonization was determined for cases and controls and was compared using Fisher\'s exact test.
UNASSIGNED: A total of 201 patients, including 104 patients with IBD and 97 non-IBD controls, were prospectively included. Females comprised 55.5% of the study participants (58% vs. 55.2% for controls, P = 0.94). Fifty-seven (54.8%) patients had ulcerative colitis, and 45 (43.2%) had Crohn\'s disease. The mean age was 43.2 +-18.2 years. Endoscopically active disease was documented in 56 cases (56%). HPV colonization was detected in four (4.1% subjects in controls vs. none in the cases, P = 0.05).
UNASSIGNED: There was no evidence of HPV ileocolonic colonization in this cohort of patients with IBD, regardless of disease activity. HPV colonization does not appear to be linked to IBD diagnosis or disease severity.
摘要：
■尽管有关炎症性肠病（IBD）的合理环境诱因的许多研究都集中在细菌病原体上，人类乳头瘤病毒(HPV)肠道定植与IBD之间的关系以前尚未被研究过.在这项研究中,我们旨在研究HPV回肠结肠定植与IBD之间的关联.
■我们进行了一项横断面研究，纳入已确诊IBD的连续患者，这些患者被转诊进行内镜评估。在内窥镜检查期间，在病例中，粘膜活检是从最发炎的结肠或回肠节段获得的，而在对照组中，则是从直肠乙状结肠区获得的。使用杂合捕获测定法来检测组织HPV。确定病例和对照组的HPV定植患病率，并使用Fisher精确检验进行比较。
■总共201名患者，包括104例IBD患者和97例非IBD对照，被前瞻性地包括在内。女性占研究参与者的55.5％（58％与对照组为55.2%，P=0.94）。57例（54.8%）患者患有溃疡性结肠炎，45例（43.2%）患有克罗恩病。平均年龄为43.2+-18.2岁。在56例（56％）中记录了内镜活动性疾病。在四个人中检测到HPV定植（对照组中4.1％的受试者与在这种情况下没有，P=0.05)。
■在IBD患者队列中没有HPV回肠结肠定植的证据，不管疾病活动。HPV定植似乎与IBD诊断或疾病严重程度无关。
■我们进行了一项横断面研究，纳入已确诊IBD的连续患者，这些患者被转诊进行内镜评估。在内窥镜检查期间，在病例中，粘膜活检是从最发炎的结肠或回肠节段获得的，而在对照组中，则是从直肠乙状结肠区获得的。使用杂合捕获测定法来检测组织HPV。确定病例和对照组的HPV定植患病率，并使用Fisher精确检验进行比较。
■总共201名患者，包括104例IBD患者和97例非IBD对照，被前瞻性地包括在内。女性占研究参与者的55.5％（58％与对照组为55.2%，P=0.94）。57例（54.8%）患者患有溃疡性结肠炎，45例（43.2%）患有克罗恩病。平均年龄为43.2+-18.2岁。在56例（56％）中记录了内镜活动性疾病。在四个人中检测到HPV定植（对照组中4.1％的受试者与在这种情况下没有，P=0.05)。
■在IBD患者队列中没有HPV回肠结肠定植的证据，不管疾病活动。HPV定植似乎与IBD诊断或疾病严重程度无关。
