PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the congenital heart defect (CHD) prevalence and identify the associated risk factors in children within the multi-ethnic Yunnan Region of China.
UNASSIGNED: This is a prospective matched case-control screening study. Screening for CHD in children residing within 28 county districts of Yunnan Province during the period of January 2001 to December 2016 was conducted. A total of 2,421 and CHD cohort and 24,210 control cohort were derived from a total population of 400,855 children (under 18 years of age).
UNASSIGNED: A total of 2,421 children were diagnosed with CHD, yielding a CHD prevalence of 6.04 cases per 1,000 children. The prevalence of CHD by sex was 6.54 per 1,000 females versus 5.59 per 1,000 males. The ethnic groups displaying the highest CHD prevalence were the Lisu (15.51 per 1,000), Achang (13.18 per 1,000), Jingpo (12.32 per 1,000), Naxi (9.68 per 1,000), and Tibetan (8.57 per 1,000), respectively. The most common CHD was atrial septal defect, amounting to 1.94 instances per 1,000 children. We identified a number of child-associated parameters that significantly correlated with greater CHD risk, such as lower mass at birth, shorter duration of gestation, and younger age at the time of screening. We also identified a number of maternal and familial risk factors.
UNASSIGNED: This ultrasonic color Doppler imaging study revealed a relatively commonplace prevalence of CHD. Moreover, the prevalence of CHD in Yunnan Region significantly varied with sex and ethnic status. Certain child-associated, maternal, and familial risk factors may contribute to CHD risk.
UNASSIGNED: This is a prospective matched case-control screening study. Screening for CHD in children residing within 28 county districts of Yunnan Province during the period of January 2001 to December 2016 was conducted. A total of 2,421 and CHD cohort and 24,210 control cohort were derived from a total population of 400,855 children (under 18 years of age).
UNASSIGNED: A total of 2,421 children were diagnosed with CHD, yielding a CHD prevalence of 6.04 cases per 1,000 children. The prevalence of CHD by sex was 6.54 per 1,000 females versus 5.59 per 1,000 males. The ethnic groups displaying the highest CHD prevalence were the Lisu (15.51 per 1,000), Achang (13.18 per 1,000), Jingpo (12.32 per 1,000), Naxi (9.68 per 1,000), and Tibetan (8.57 per 1,000), respectively. The most common CHD was atrial septal defect, amounting to 1.94 instances per 1,000 children. We identified a number of child-associated parameters that significantly correlated with greater CHD risk, such as lower mass at birth, shorter duration of gestation, and younger age at the time of screening. We also identified a number of maternal and familial risk factors.
UNASSIGNED: This ultrasonic color Doppler imaging study revealed a relatively commonplace prevalence of CHD. Moreover, the prevalence of CHD in Yunnan Region significantly varied with sex and ethnic status. Certain child-associated, maternal, and familial risk factors may contribute to CHD risk.
摘要：
■确定中国云南多民族地区儿童的先天性心脏病（CHD）患病率并确定相关危险因素。
■这是一项前瞻性配对病例对照筛选研究。对2001年1月至2016年12月云南省28个县区儿童进行冠心病筛查。共有2,421名CHD和24,210名对照队列来自400,855名儿童（18岁以下）的总人口。
■共有2,421名儿童被诊断为冠心病，CHD患病率为每1000名儿童6.04例。按性别划分的CHD患病率为每1000名女性6.54，而每1000名男性为5.59。CHD患病率最高的种族是Lisu族（每1000人中有15.51人），阿昌（13.18/1000），景颇（12.32/1000），纳西（每1000人中有9.68人），和藏语（千分之8.57），分别。最常见的CHD是房间隔缺损,相当于每1000名儿童1.94例。我们确定了一些与儿童相关的参数，这些参数与更高的CHD风险显着相关，比如出生时质量较低，妊娠持续时间较短，筛查时年龄较小。我们还确定了一些孕产妇和家族风险因素。
■这项超声彩色多普勒成像研究揭示了冠心病的患病率相对普遍。此外，云南地区冠心病患病率随性别和民族状况的不同而有显著差异。某些与孩子相关的，母性,和家族性危险因素可能导致CHD风险。
■这是一项前瞻性配对病例对照筛选研究。对2001年1月至2016年12月云南省28个县区儿童进行冠心病筛查。共有2,421名CHD和24,210名对照队列来自400,855名儿童（18岁以下）的总人口。
■共有2,421名儿童被诊断为冠心病，CHD患病率为每1000名儿童6.04例。按性别划分的CHD患病率为每1000名女性6.54，而每1000名男性为5.59。CHD患病率最高的种族是Lisu族（每1000人中有15.51人），阿昌（13.18/1000），景颇（12.32/1000），纳西（每1000人中有9.68人），和藏语（千分之8.57），分别。最常见的CHD是房间隔缺损,相当于每1000名儿童1.94例。我们确定了一些与儿童相关的参数，这些参数与更高的CHD风险显着相关，比如出生时质量较低，妊娠持续时间较短，筛查时年龄较小。我们还确定了一些孕产妇和家族风险因素。
■这项超声彩色多普勒成像研究揭示了冠心病的患病率相对普遍。此外，云南地区冠心病患病率随性别和民族状况的不同而有显著差异。某些与孩子相关的，母性,和家族性危险因素可能导致CHD风险。
