PDF(Pubmed)
Abstract：
Granulocyte colony-stimulating factor (G-CSF) promotes neutrophil production. G-CSF-producing tumors have a feature of neutrophilia without infection, and most patients with G-CSF-producing tumors show an aggressive clinical course and poor prognosis. A 71-year-old woman was diagnosed with left lung cancer, cT4N1M0, stage IIIA. Severe neutrophilia and bone marrow uptake in 18-fluorodeoxyglucose-positron emission tomography suggested the possibility of G-CSF-producing lung cancer. Following neoadjuvant radiation chemotherapy, left lower lobectomy and left upper lobe partial resection were performed. According to pathology findings of the resected specimen, the patient was diagnosed with G-CSF-producing left lung squamous cell carcinoma. Moreover, genetic tests showed that the tumor cells were positive for c-ros oncogene 1 (ROS1) rearrangements. To our knowledge, this is the first reported case of G-CSF-producing lung cancer with ROS1 rearrangements, and complete resection was performed successfully after neoadjuvant radiation chemotherapy.
摘要：
粒细胞集落刺激因子(G-CSF)促进中性粒细胞产生。产生G-CSF的肿瘤有中性粒细胞增多的特征，没有感染，大多数产生G-CSF的肿瘤患者表现出积极的临床病程和不良预后。一名71岁的妇女被诊断出患有左肺癌，cT4N1M0，IIIA期。18氟脱氧葡萄糖-正电子发射断层扫描中严重的中性粒细胞增多和骨髓摄取提示可能产生G-CSF的肺癌。新辅助放疗后，左下叶切除和左上叶部分切除。根据切除标本的病理结果，患者被诊断为产生G-CSF的左肺鳞状细胞癌.此外，基因检测显示肿瘤细胞c-ros癌基因1(ROS1)重排阳性。据我们所知,这是第一例报道的G-CSF产生性肺癌与ROS1重排，新辅助放化疗后成功进行了完全切除。
