PDF(Pubmed)
Abstract：
OBJECTIVE: IVM preceded by a prematuration step (capacitation [CAPA]-IVM) improves the acquisition of oocyte developmental competence and can enhance embryo quality. There is currently no follow-up data on babies born from CAPA-IVM. This study investigated developmental outcomes in children born after CAPA-IVM versus natural conception.
METHODS: This prospective cohort study was conducted at a fertility clinic in Vietnam in August/September 2019. Children born after CAPA-IVM were propensity score-matched with those born after natural conception. All parents were asked to complete the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires.
RESULTS: A total of 46 parents (23 in each group) of 55 babies (31 CAPA-IVM and 24 natural conception) were included in the study. Baseline characteristics, including mother\'s age and body mass index, gestational age at delivery, and birth weight, were comparable. The mean age of children at the end of follow-up was 15 months. The overall proportion of children with any abnormal ASQ-3 score was 6.5% in the CAPA-IVM group and 20.8% in the natural conception group (p = 0.24). The proportion of children with a developmental red flag did not differ significantly between the CAPA-IVM and natural conception groups (9.7% vs. 4.2%; p = 0.80).
CONCLUSIONS: The use of CAPA-IVM did not have any significant impact on childhood physical and mental development compared with children born as a result of natural conception.
METHODS: This prospective cohort study was conducted at a fertility clinic in Vietnam in August/September 2019. Children born after CAPA-IVM were propensity score-matched with those born after natural conception. All parents were asked to complete the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires.
RESULTS: A total of 46 parents (23 in each group) of 55 babies (31 CAPA-IVM and 24 natural conception) were included in the study. Baseline characteristics, including mother\'s age and body mass index, gestational age at delivery, and birth weight, were comparable. The mean age of children at the end of follow-up was 15 months. The overall proportion of children with any abnormal ASQ-3 score was 6.5% in the CAPA-IVM group and 20.8% in the natural conception group (p = 0.24). The proportion of children with a developmental red flag did not differ significantly between the CAPA-IVM and natural conception groups (9.7% vs. 4.2%; p = 0.80).
CONCLUSIONS: The use of CAPA-IVM did not have any significant impact on childhood physical and mental development compared with children born as a result of natural conception.
摘要：
目的：IVM之前有一个早熟步骤（获能[CAPA]-IVM）可以提高卵母细胞发育能力的获得，并可以提高胚胎质量。目前没有CAPA-IVM出生婴儿的后续数据。这项研究调查了CAPA-IVM与自然受孕后出生的儿童的发育结果。
方法：这项前瞻性队列研究于2019年8月/9月在越南的生育诊所进行。CAPA-IVM后出生的儿童与自然受孕后出生的儿童倾向得分相匹配。所有父母都被要求完成发育红旗和年龄和阶段第三版(ASQ-3)问卷。
结果：共有46名父母（每组23名）55名婴儿（31名CAPA-IVM和24名自然受孕）被纳入研究。基线特征，包括母亲的年龄和体重指数，分娩时的胎龄，出生体重,是可比的。随访结束时儿童的平均年龄为15个月。在CAPA-IVM组中，ASQ-3评分异常的儿童的总比例为6.5％，在自然受孕组中为20.8％（p=0.24）。CAPA-IVM和自然受孕组之间具有发育红旗的儿童比例没有显着差异（9.7％与4.2%；p=0.80）。
结论：与自然受孕出生的儿童相比，CAPA-IVM的使用对儿童身心发育没有任何显著影响。
方法：这项前瞻性队列研究于2019年8月/9月在越南的生育诊所进行。CAPA-IVM后出生的儿童与自然受孕后出生的儿童倾向得分相匹配。所有父母都被要求完成发育红旗和年龄和阶段第三版(ASQ-3)问卷。
结果：共有46名父母（每组23名）55名婴儿（31名CAPA-IVM和24名自然受孕）被纳入研究。基线特征，包括母亲的年龄和体重指数，分娩时的胎龄，出生体重,是可比的。随访结束时儿童的平均年龄为15个月。在CAPA-IVM组中，ASQ-3评分异常的儿童的总比例为6.5％，在自然受孕组中为20.8％（p=0.24）。CAPA-IVM和自然受孕组之间具有发育红旗的儿童比例没有显着差异（9.7％与4.2%；p=0.80）。
结论：与自然受孕出生的儿童相比，CAPA-IVM的使用对儿童身心发育没有任何显著影响。
