PDF(Pubmed)
Abstract：
UNASSIGNED: Existing evidence on the association between blood pressure (BP) and mortality risk in intensive care unit (ICU) patients with atrial fibrillation (AF) is scarce.
UNASSIGNED: This study aimed to assess the associations between blood pressure (BP) and risks of in-hospital and all-cause mortality in ICU patients with AF.
UNASSIGNED: A total of 2,345 records of patients with AF whose BP was monitored after admission to the ICU were obtained from the MIMIC-III database. Incidences were calculated for endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). We performed smooth curve and logistic regression analyses to evaluate the association between BP and the risk of each endpoint.
UNASSIGNED: Smooth curve regression showed that systolic blood pressure (SBP), mean arterial pressure (MBP), and diastolic blood pressure (DBP) followed U-shaped curves with respect to endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). The incidence of these endpoints was lowest at 110/70/55 mm Hg. There was an increased risk of 1-year mortality observed with BP > 110/70/55 mm Hg (SBP, odds ratio [OR] = 1.008, 95% CI 1.001-1.015, p = 0.0022; MBP, OR = 1.010, 95% CI 1.005-1.016, p < 0.001) after adjusting for age, sex, and medical history. In contrast, an inverse association between BP and the risk of 1-year mortality was observed with BP ≤ 110/70/55 mm Hg (SBP, OR = 0.981, 95% CI 0.974-0.988, p < 0.001; MBP OR = 0.959, 95% CI 0.939-0.979, p < 0.001; and DBP, OR = 0.970, 95% CI 0.957-0.983, p < 0.001).
UNASSIGNED: We observed a U-shaped association between BP and in-hospital/all-cause mortality in ICU patients with AF. However, the underlying causes need to be investigated.
UNASSIGNED: This study aimed to assess the associations between blood pressure (BP) and risks of in-hospital and all-cause mortality in ICU patients with AF.
UNASSIGNED: A total of 2,345 records of patients with AF whose BP was monitored after admission to the ICU were obtained from the MIMIC-III database. Incidences were calculated for endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). We performed smooth curve and logistic regression analyses to evaluate the association between BP and the risk of each endpoint.
UNASSIGNED: Smooth curve regression showed that systolic blood pressure (SBP), mean arterial pressure (MBP), and diastolic blood pressure (DBP) followed U-shaped curves with respect to endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). The incidence of these endpoints was lowest at 110/70/55 mm Hg. There was an increased risk of 1-year mortality observed with BP > 110/70/55 mm Hg (SBP, odds ratio [OR] = 1.008, 95% CI 1.001-1.015, p = 0.0022; MBP, OR = 1.010, 95% CI 1.005-1.016, p < 0.001) after adjusting for age, sex, and medical history. In contrast, an inverse association between BP and the risk of 1-year mortality was observed with BP ≤ 110/70/55 mm Hg (SBP, OR = 0.981, 95% CI 0.974-0.988, p < 0.001; MBP OR = 0.959, 95% CI 0.939-0.979, p < 0.001; and DBP, OR = 0.970, 95% CI 0.957-0.983, p < 0.001).
UNASSIGNED: We observed a U-shaped association between BP and in-hospital/all-cause mortality in ICU patients with AF. However, the underlying causes need to be investigated.
摘要：
■关于重症监护病房（ICU）房颤（AF）患者血压（BP）与死亡风险之间关联的现有证据很少。
本研究旨在评估ICU房颤患者的血压（BP）与住院风险和全因死亡率之间的关系。
■从MIMIC-III数据库中获得了2,345例房颤患者的记录，这些患者在入住ICU后进行了血压监测。计算终点的发病率(医院死亡率，7天死亡率，30天死亡率，和1年死亡率)。我们进行了平滑曲线和逻辑回归分析，以评估BP与每个终点风险之间的关联。
■平滑曲线回归显示收缩压（SBP），平均动脉压（MBP），和舒张压（DBP）相对于终点（医院死亡率，7天死亡率，30天死亡率，和1年死亡率)。这些终点的发生率最低为110/70/55mmHg。血压>110/70/55mmHg（SBP，比值比[OR]=1.008，95%CI1.001-1.015，p=0.0022；MBP，OR=1.010，95%CI1.005-1.016，p<0.001)调整年龄后，性别,和病史。相比之下,BP≤110/70/55mmHg（SBP，OR=0.981,95%CI0.974-0.988,p<0.001;MBPOR=0.959,95%CI0.939-0.979,p<0.001;DBP,OR=0.970，95%CI0.957-0.983，p<0.001)。
■我们观察到ICU房颤患者血压与住院/全因死亡率呈U型关联。然而,根本原因需要调查。
本研究旨在评估ICU房颤患者的血压（BP）与住院风险和全因死亡率之间的关系。
■从MIMIC-III数据库中获得了2,345例房颤患者的记录，这些患者在入住ICU后进行了血压监测。计算终点的发病率(医院死亡率，7天死亡率，30天死亡率，和1年死亡率)。我们进行了平滑曲线和逻辑回归分析，以评估BP与每个终点风险之间的关联。
■平滑曲线回归显示收缩压（SBP），平均动脉压（MBP），和舒张压（DBP）相对于终点（医院死亡率，7天死亡率，30天死亡率，和1年死亡率)。这些终点的发生率最低为110/70/55mmHg。血压>110/70/55mmHg（SBP，比值比[OR]=1.008，95%CI1.001-1.015，p=0.0022；MBP，OR=1.010，95%CI1.005-1.016，p<0.001)调整年龄后，性别,和病史。相比之下,BP≤110/70/55mmHg（SBP，OR=0.981,95%CI0.974-0.988,p<0.001;MBPOR=0.959,95%CI0.939-0.979,p<0.001;DBP,OR=0.970，95%CI0.957-0.983，p<0.001)。
■我们观察到ICU房颤患者血压与住院/全因死亡率呈U型关联。然而,根本原因需要调查。
