Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients With and Without Cryptococcosis.

有和没有隐球菌病的器官移植受者中新生隐球菌特异性和非新生隐球菌特异性抗体谱。

• 影响指数: 4.423
• 发表时间: Jul 2022
• 来源期刊: Open Forum Infect Dis
• DOI: 10.1093/ofid/ofac211
• PMID: 35794949
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Yoon H,Nakouzi A,Pappas PG,Hemmige VS,Pirofski LA,Yoon H,Nakouzi A,Pappas PG,Hemmige VS,Pirofski LA

关键词: IgM; cryptococcosis; glucuronoxylomannan; laminarin; transplant recipients; IgM; cryptococcosis; glucuronoxylomannan; laminarin; transplant recipients

Abstract

Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.

摘要

尚未在患有隐球菌病的器官移植受体（OTR）中研究抗体免疫。我们确定了OTR中的血清抗体水平：23例隐球菌病病例和21例对照。葡糖醛酸木甘露聚糖免疫球蛋白M(IgM)和海带多糖IgM均低于对照组,与隐球菌病状态呈负相关，并可能作为隐球菌病的标志。