Abstract：
BACKGROUND: It is plausible that immunopathological processes associated with psoriasis might contribute to the occurrence of olfactory or taste dysfunction. However, the actual association was still unknown.
OBJECTIVE: To determine the relationship between olfactory or taste dysfunction and psoriasis.
METHODS: Two cross-sectional studies were performed by using National Health and Nutrition Examination Survey (NHANES) data. Participants with psoriasis were defined as cases and those without psoriasis were identified as controls. Taste and smell self-reported questionnaires were used to define smell/taste alterations and identification tests were used to assure the smell/taste dysfunctions. Logistic regression models with inverse probability treatment weighting (IPTW) strategies were conducted to investigated the relationship between psoriasis and olfactory or taste dysfunction.
RESULTS: Self-reported questionnaires indicated that psoriasis patients were more likely to have perceived taste alteration (IPTW-aOR = 1.43) and smell alteration (IPTW-aOR = 1.22). Identification tests revealed that psoriasis was associated with taste dysfunction (IPTW-aOR = 1.28) and olfactory dysfunction (IPTW-aOR = 1.22). Relevant findings showed that psoriasis may be significantly associated with taste or olfactory dysfunction regardless of the questionnaire data or identification examination data used.
CONCLUSIONS: Olfactory and taste dysfunction could be considered comorbidities in patients with psoriasis based on our observational study. Therefore, physicians should be cautious of olfaction and taste alterations among patients with psoriasis.
OBJECTIVE: To determine the relationship between olfactory or taste dysfunction and psoriasis.
METHODS: Two cross-sectional studies were performed by using National Health and Nutrition Examination Survey (NHANES) data. Participants with psoriasis were defined as cases and those without psoriasis were identified as controls. Taste and smell self-reported questionnaires were used to define smell/taste alterations and identification tests were used to assure the smell/taste dysfunctions. Logistic regression models with inverse probability treatment weighting (IPTW) strategies were conducted to investigated the relationship between psoriasis and olfactory or taste dysfunction.
RESULTS: Self-reported questionnaires indicated that psoriasis patients were more likely to have perceived taste alteration (IPTW-aOR = 1.43) and smell alteration (IPTW-aOR = 1.22). Identification tests revealed that psoriasis was associated with taste dysfunction (IPTW-aOR = 1.28) and olfactory dysfunction (IPTW-aOR = 1.22). Relevant findings showed that psoriasis may be significantly associated with taste or olfactory dysfunction regardless of the questionnaire data or identification examination data used.
CONCLUSIONS: Olfactory and taste dysfunction could be considered comorbidities in patients with psoriasis based on our observational study. Therefore, physicians should be cautious of olfaction and taste alterations among patients with psoriasis.
摘要：
背景：与银屑病相关的免疫病理过程可能有助于嗅觉或味觉功能障碍的发生。然而,实际关联仍然未知。
目的：探讨嗅觉或味觉功能障碍与银屑病的关系。
方法：使用国家健康和营养调查（NHANES）数据进行了两项横断面研究。患有银屑病的参与者被定义为病例，没有银屑病的参与者被确定为对照。使用味觉和气味自我报告问卷来定义气味/味道变化，并使用鉴定测试来确保气味/味觉功能障碍。采用逆概率加权（IPTW）策略的Logistic回归模型来研究银屑病与嗅觉或味觉功能障碍之间的关系。
结果：自我报告问卷显示，银屑病患者更容易出现味觉改变（IPTW-aOR=1.43）和嗅觉改变（IPTW-aOR=1.22）。鉴定测试显示，银屑病与味觉功能障碍（IPTW-aOR=1.28）和嗅觉功能障碍（IPTW-aOR=1.22）有关。相关发现表明，无论使用的问卷调查数据或鉴定检查数据如何，牛皮癣都可能与味觉或嗅觉功能障碍显着相关。
结论：根据我们的观察性研究，嗅觉和味觉功能障碍可被认为是银屑病患者的合并症。因此,医师应谨慎注意银屑病患者的嗅觉和味觉改变。
目的：探讨嗅觉或味觉功能障碍与银屑病的关系。
方法：使用国家健康和营养调查（NHANES）数据进行了两项横断面研究。患有银屑病的参与者被定义为病例，没有银屑病的参与者被确定为对照。使用味觉和气味自我报告问卷来定义气味/味道变化，并使用鉴定测试来确保气味/味觉功能障碍。采用逆概率加权（IPTW）策略的Logistic回归模型来研究银屑病与嗅觉或味觉功能障碍之间的关系。
结果：自我报告问卷显示，银屑病患者更容易出现味觉改变（IPTW-aOR=1.43）和嗅觉改变（IPTW-aOR=1.22）。鉴定测试显示，银屑病与味觉功能障碍（IPTW-aOR=1.28）和嗅觉功能障碍（IPTW-aOR=1.22）有关。相关发现表明，无论使用的问卷调查数据或鉴定检查数据如何，牛皮癣都可能与味觉或嗅觉功能障碍显着相关。
结论：根据我们的观察性研究，嗅觉和味觉功能障碍可被认为是银屑病患者的合并症。因此,医师应谨慎注意银屑病患者的嗅觉和味觉改变。
