PDF(Pubmed)
Abstract：
Kawasaki disease (KD) and multisystem inflammatory syndrome (MIS) are rare conditions that occur predominately in children. Recent reports document KD and MIS in adult patients following infection with SARS-CoV-2. Rarely, MIS is observed following vaccination against SARS-CoV-2, mostly in patients with prior SARS-CoV-2 infection. We report a case of KD in a man after a second SARS-CoV-2 vaccine dose, in absence of concurrent or prior SARS-CoV-2 infection. This patient also met criteria for probable MIS associated with vaccination. He tested negative for SARS-CoV-2 RNA via reverse transcriptase PCR, negative for SARS-CoV-2 nucleocapsid antibodies and demonstrated high levels SARS-CoV-2 spike protein antibodies, commonly used to assess vaccine response. Symptom improvement followed treatment with intravenous immunoglobulin, including desquamation of the hands and feet. As widespread vaccination against SARS-CoV-2 continues, increased vigilance and prompt intervention is necessary to limit the effects of postvaccination inflammatory syndromes.
摘要：
川崎病（KD）和多系统炎症综合征（MIS）是罕见的疾病，主要发生在儿童中。最近的报告记录了感染SARS-CoV-2后成年患者的KD和MIS。很少,在针对SARS-CoV-2的疫苗接种后观察到MIS,主要在先前患有SARS-CoV-2感染的患者中。我们报告了一名男子在第二次SARS-CoV-2疫苗剂量后的KD病例，没有并发或先前的SARS-CoV-2感染。该患者也符合与疫苗接种相关的可能MIS的标准。他通过逆转录酶PCR检测出SARS-CoV-2RNA呈阴性，SARS-CoV-2核衣壳抗体阴性，并显示出高水平的SARS-CoV-2刺突蛋白抗体，通常用于评估疫苗反应。静脉免疫球蛋白治疗后症状改善，包括手和脚的脱皮。随着SARS-CoV-2的广泛疫苗接种继续，提高警惕和及时干预对于限制疫苗接种后炎症综合征的影响是必要的.
