PDF(Pubmed)
Abstract：
UNASSIGNED: Emerging evidence indicates that gut dysbiosis is involved in the occurrence and development of diabetic kidney diseases (DKD). However, the key microbial taxa closely related to DKD have not been determined.
UNASSIGNED: PubMed, Web of Science, Cochrane, Chinese Biomedical Databases, China National Knowledge Internet, and Embase were searched for case-control or cross-sectional studies comparing the gut microbiota of patients with DKD and healthy controls (HC) from inception to February 8, 2022, and random/fixed-effects meta-analysis on the standardized mean difference (SMD) were performed for alpha diversity indexes between DKD and HC, and beta diversity indexes and the relative abundance of gut microbiota were extracted and summarized qualitatively.
UNASSIGNED: A total of 16 studies (578 patients with DKD and 444 HC) were included. Compared to HC, the bacterial richness of patients with DKD was significantly decreased, and the diversity indexes were decreased but not statistically, companying with a distinct beta diversity. The relative abundance of phylum Proteobacteria, Actinobacteria, and Bacteroidetes, family Coriobacteriaceae, Enterobacteriaceae, and Veillonellaceae, genus Enterococcus, Citrobacter, Escherichia, Klebsiella, Akkermansia, Sutterella, and Acinetobacter, and species E. coli were enriched while that of phylum Firmicutes, family Lachnospiraceae, genus Roseburia, Prevotella, and Bifidobacterium were depleted in patients with DKD.
UNASSIGNED: The gut microbiota of patients with DKD may possess specific features characterized by expansion of genus Escherichia, Citrobacter, and Klebsiella, and depletion of Roseburia, which may contribute most to the alterations of their corresponding family and phylum taxa, as well as the bacterial diversity and composition. These microbial taxa may be closely related to DKD and serve as promising targets for the management of DKD.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42021289863.
UNASSIGNED: PubMed, Web of Science, Cochrane, Chinese Biomedical Databases, China National Knowledge Internet, and Embase were searched for case-control or cross-sectional studies comparing the gut microbiota of patients with DKD and healthy controls (HC) from inception to February 8, 2022, and random/fixed-effects meta-analysis on the standardized mean difference (SMD) were performed for alpha diversity indexes between DKD and HC, and beta diversity indexes and the relative abundance of gut microbiota were extracted and summarized qualitatively.
UNASSIGNED: A total of 16 studies (578 patients with DKD and 444 HC) were included. Compared to HC, the bacterial richness of patients with DKD was significantly decreased, and the diversity indexes were decreased but not statistically, companying with a distinct beta diversity. The relative abundance of phylum Proteobacteria, Actinobacteria, and Bacteroidetes, family Coriobacteriaceae, Enterobacteriaceae, and Veillonellaceae, genus Enterococcus, Citrobacter, Escherichia, Klebsiella, Akkermansia, Sutterella, and Acinetobacter, and species E. coli were enriched while that of phylum Firmicutes, family Lachnospiraceae, genus Roseburia, Prevotella, and Bifidobacterium were depleted in patients with DKD.
UNASSIGNED: The gut microbiota of patients with DKD may possess specific features characterized by expansion of genus Escherichia, Citrobacter, and Klebsiella, and depletion of Roseburia, which may contribute most to the alterations of their corresponding family and phylum taxa, as well as the bacterial diversity and composition. These microbial taxa may be closely related to DKD and serve as promising targets for the management of DKD.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42021289863.
摘要：
新的证据表明，肠道菌群失调与糖尿病肾脏疾病（DKD）的发生和发展有关。然而,与DKD密切相关的关键微生物类群尚未确定。
PubMed,WebofScience,科克伦,中国生物医学数据库,中国全民知识互联网,和Embase搜索病例对照或横断面研究，比较DKD患者和健康对照（HC）从开始到2022年2月8日的肠道微生物群，并对标准平均差异（SMD）进行随机/固定效应荟萃分析DKD和HC之间的α多样性指数，并对β多样性指数和肠道菌群相对丰度进行了定性提取和总结。
共纳入16项研究（578例DKD患者和444例HC患者）。与HC相比，DKD患者的细菌丰富度显着下降，多样性指数有所下降，但没有统计学意义，具有独特的β多样性。蛋白质门细菌的相对丰度，放线菌,和拟杆菌,科细菌科，肠杆菌科,和Veillonellaceae，肠球菌属,柠檬酸杆菌,埃希氏菌,克雷伯菌属,Akkermansia,Sutterilla,和不动杆菌，大肠杆菌被富集，而Firmicutes门被富集，天花科，Roseburia属,普雷沃氏菌,DKD患者的双歧杆菌被耗尽。
DKD患者的肠道菌群可能具有以埃希氏菌属扩展为特征的特定特征，柠檬酸杆菌,和克雷伯菌属,和Roseburia的枯竭，这可能对其相应的家族和门类群的改变做出了最大的贡献，以及细菌的多样性和组成。这些微生物类群可能与DKD密切相关，并可作为DKD管理的有希望的目标。
https://www。crd.约克。AC.英国/普华永道/，标识符CRD42021289863。
PubMed,WebofScience,科克伦,中国生物医学数据库,中国全民知识互联网,和Embase搜索病例对照或横断面研究，比较DKD患者和健康对照（HC）从开始到2022年2月8日的肠道微生物群，并对标准平均差异（SMD）进行随机/固定效应荟萃分析DKD和HC之间的α多样性指数，并对β多样性指数和肠道菌群相对丰度进行了定性提取和总结。
共纳入16项研究（578例DKD患者和444例HC患者）。与HC相比，DKD患者的细菌丰富度显着下降，多样性指数有所下降，但没有统计学意义，具有独特的β多样性。蛋白质门细菌的相对丰度，放线菌,和拟杆菌,科细菌科，肠杆菌科,和Veillonellaceae，肠球菌属,柠檬酸杆菌,埃希氏菌,克雷伯菌属,Akkermansia,Sutterilla,和不动杆菌，大肠杆菌被富集，而Firmicutes门被富集，天花科，Roseburia属,普雷沃氏菌,DKD患者的双歧杆菌被耗尽。
DKD患者的肠道菌群可能具有以埃希氏菌属扩展为特征的特定特征，柠檬酸杆菌,和克雷伯菌属,和Roseburia的枯竭，这可能对其相应的家族和门类群的改变做出了最大的贡献，以及细菌的多样性和组成。这些微生物类群可能与DKD密切相关，并可作为DKD管理的有希望的目标。
https://www。crd.约克。AC.英国/普华永道/，标识符CRD42021289863。
