PDF(Pubmed)
Abstract：
UNASSIGNED: The kidney is well-known as the vital organ which is responsible for maintaining body homeostasis and secretion of toxic metabolites. Renal injury is accompanied by oxidative stress which results in cellular apoptosis, lipid peroxidation, and reduction of antioxidant levels. Plant extracts and their phytoconstituents, owing to free radical scavenging properties, seem to be valuable against modern synthetic and chemical drugs. Naringin is a flavonoid present in citrus fruits with pharmacologic effects including antioxidant, anti-inflammatory, and anti-apoptotic properties. This review summarizes the renoprotective effects of naringin and discusses mechanisms of its action against renal injury.
UNASSIGNED: For this paper, original subject-related articles published up to October 2020 have been reviewed in the databases, including PubMed, Scopus, and Web of Science, and Google Scholar.
UNASSIGNED: Naringin increases antioxidant enzyme activity, and glutathione content, reduces lipid peroxidation and inhibits inflammatory cytokines. In the molecular investigation, naringin activates the Nrf-2 signaling, prevents apoptosis signaling, and inhibits the autophagy pathway. Besides, naringin could protect the kidney through modulating microRNA-10a in the kidney tissue in an acute kidney injury model.
UNASSIGNED: This review recommends that naringin can be considered a promising candidate to treat kidney dysfunction induced by oxidative stress in the future.
UNASSIGNED: For this paper, original subject-related articles published up to October 2020 have been reviewed in the databases, including PubMed, Scopus, and Web of Science, and Google Scholar.
UNASSIGNED: Naringin increases antioxidant enzyme activity, and glutathione content, reduces lipid peroxidation and inhibits inflammatory cytokines. In the molecular investigation, naringin activates the Nrf-2 signaling, prevents apoptosis signaling, and inhibits the autophagy pathway. Besides, naringin could protect the kidney through modulating microRNA-10a in the kidney tissue in an acute kidney injury model.
UNASSIGNED: This review recommends that naringin can be considered a promising candidate to treat kidney dysfunction induced by oxidative stress in the future.
摘要：
■众所周知，肾脏是负责维持身体稳态和分泌有毒代谢物的重要器官。肾损伤伴随着氧化应激导致细胞凋亡,脂质过氧化，和降低抗氧化剂水平。植物提取物及其植物成分，由于自由基清除性能，似乎对现代合成和化学药物有价值。柚皮苷是柑橘类水果中存在的黄酮类化合物，具有包括抗氧化剂在内的药理作用。抗炎,和抗凋亡特性。本文综述了柚皮苷的肾脏保护作用，并讨论了其对肾脏损伤的作用机制。
■对于本文，截至2020年10月发表的与主题相关的原创文章已经在数据库中进行了审查，包括PubMed,Scopus,和WebofScience,谷歌学者。
■柚皮苷增加抗氧化酶活性，和谷胱甘肽含量，减少脂质过氧化并抑制炎性细胞因子。在分子研究中，柚皮苷激活Nrf-2信号，阻止凋亡信号，并抑制自噬途径。此外,在急性肾损伤模型中，柚皮苷通过调节肾组织中的microRNA-10a来保护肾脏。
■这篇综述建议柚皮苷可以被认为是未来治疗氧化应激引起的肾功能障碍的有希望的候选药物。
■对于本文，截至2020年10月发表的与主题相关的原创文章已经在数据库中进行了审查，包括PubMed,Scopus,和WebofScience,谷歌学者。
■柚皮苷增加抗氧化酶活性，和谷胱甘肽含量，减少脂质过氧化并抑制炎性细胞因子。在分子研究中，柚皮苷激活Nrf-2信号，阻止凋亡信号，并抑制自噬途径。此外,在急性肾损伤模型中，柚皮苷通过调节肾组织中的microRNA-10a来保护肾脏。
■这篇综述建议柚皮苷可以被认为是未来治疗氧化应激引起的肾功能障碍的有希望的候选药物。
