PDF(Pubmed)
Abstract：
UNASSIGNED: Research on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in depression is still emerging and has increased 3-fold since the first meta-analysis. An updated meta-analysis with sufficient studies can provide more evidence for a potential relationship between NLR, PLR, MLR, and depression.
UNASSIGNED: We identified 18 studies from the PubMed, EMBASE, Cochrane library, and Web of Science databases. Meta-analyses were performed to generate pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) between patients with depression and controls. Sensitivity analysis, subgroup analysis, meta-regression, and publication bias were conducted.
UNASSIGNED: A total of 18 studies including 2,264 depressed patients and 2,415 controls were included. Depressed patients had significantly higher NLR and PLR compared with controls (SMD = 0.33, 95% CI: 0.15-0.52, p < 0.001 and SMD = 0.24, 95% CI: 0.02-0.46, p < 0.05, respectively). MLR was slightly higher in depressed individuals compared to controls (SMD = 0.15, 95% CI: -0.26 to 0.55, p > 0.05), despite the absence of significance. Sensitivity analysis removing one study responsible for heterogeneity showed a higher and significant effect (SMD = 0.32, 95% CI: 0.20-0.44) of MLR. Three subgroup analyses of NLR, PLR, MLR, and depression revealed obvious differences in the inflammatory ratios between depressed patients and controls in China and the matched age and gender subgroup. Individuals with post-stroke depression (PSD) had higher NLR and MLR values as compared to non-PSD patients (SMD = 0.51, 95% CI: 0.36-0.67, p < 0.001 and SMD = 0.46, 95% CI: 0.12-0.79, p < 0.01, respectively). Meta-regression analyses showed that male proportion in the case group influenced the heterogeneity among studies that measured NLR values (p < 0.05).
UNASSIGNED: Higher inflammatory ratios, especially NLR, were significantly associated with an increased risk of depression. In the subgroup of China and matched age and gender, NLR, PLR, and MLR were all elevated in depressed patients vs. controls. Individuals with PSD had higher NLR and MLR values as compared to non-PSD patients. Gender differences may have an effect on NLR values in patients with depression.
UNASSIGNED: We identified 18 studies from the PubMed, EMBASE, Cochrane library, and Web of Science databases. Meta-analyses were performed to generate pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) between patients with depression and controls. Sensitivity analysis, subgroup analysis, meta-regression, and publication bias were conducted.
UNASSIGNED: A total of 18 studies including 2,264 depressed patients and 2,415 controls were included. Depressed patients had significantly higher NLR and PLR compared with controls (SMD = 0.33, 95% CI: 0.15-0.52, p < 0.001 and SMD = 0.24, 95% CI: 0.02-0.46, p < 0.05, respectively). MLR was slightly higher in depressed individuals compared to controls (SMD = 0.15, 95% CI: -0.26 to 0.55, p > 0.05), despite the absence of significance. Sensitivity analysis removing one study responsible for heterogeneity showed a higher and significant effect (SMD = 0.32, 95% CI: 0.20-0.44) of MLR. Three subgroup analyses of NLR, PLR, MLR, and depression revealed obvious differences in the inflammatory ratios between depressed patients and controls in China and the matched age and gender subgroup. Individuals with post-stroke depression (PSD) had higher NLR and MLR values as compared to non-PSD patients (SMD = 0.51, 95% CI: 0.36-0.67, p < 0.001 and SMD = 0.46, 95% CI: 0.12-0.79, p < 0.01, respectively). Meta-regression analyses showed that male proportion in the case group influenced the heterogeneity among studies that measured NLR values (p < 0.05).
UNASSIGNED: Higher inflammatory ratios, especially NLR, were significantly associated with an increased risk of depression. In the subgroup of China and matched age and gender, NLR, PLR, and MLR were all elevated in depressed patients vs. controls. Individuals with PSD had higher NLR and MLR values as compared to non-PSD patients. Gender differences may have an effect on NLR values in patients with depression.
摘要：
■中性粒细胞与淋巴细胞比率（NLR）的研究，血小板与淋巴细胞比率（PLR），和单核细胞与淋巴细胞比率(MLR)在抑郁症中仍在出现,并且自首次荟萃分析以来已经增加了3倍.具有足够研究的更新的荟萃分析可以为NLR之间的潜在关系提供更多证据，PLR,MLR,和抑郁症。
■我们确定了来自PubMed的18项研究，EMBASE,科克伦图书馆,和WebofScience数据库。进行荟萃分析，以生成抑郁症患者和对照组之间的汇总标准化平均差（SMD）和95％置信区间（CI）。敏感性分析,亚组分析，元回归，并进行了发表偏倚。
■共纳入18项研究，包括2,264名抑郁症患者和2,415名对照。与对照组相比，抑郁患者的NLR和PLR明显更高（SMD=0.33，95％CI：0.15-0.52，p<0.001，SMD=0.24，95％CI：0.02-0.46，p<0.05）。与对照组相比，抑郁个体的MLR略高（SMD=0.15，95％CI：-0.26至0.55，p>0.05），尽管没有意义。敏感性分析删除了一项导致异质性的研究，显示了MLR的更高且显着的影响（SMD=0.32，95％CI：0.20-0.44）。NLR的三个亚组分析，PLR,MLR,和抑郁症显示，中国抑郁症患者和对照组以及匹配的年龄和性别亚组之间的炎症比率存在明显差异。与非PSD患者相比，卒中后抑郁（PSD）患者的NLR和MLR值较高（SMD=0.51，95％CI：0.36-0.67，p<0.001，SMD=0.46，95％CI：0.12-0.79，p<0.01，分别）。Meta回归分析显示，病例组中男性比例影响了测量NLR值的研究之间的异质性（p<0.05）。
■较高的炎症比率，尤其是NLR,与抑郁症风险增加显著相关。在中国亚组中，年龄和性别相匹配，NLR,PLR,与抑郁症患者相比，MLR均升高controls.与非PSD患者相比，PSD患者的NLR和MLR值较高。性别差异可能对抑郁症患者的NLR值产生影响。
■我们确定了来自PubMed的18项研究，EMBASE,科克伦图书馆,和WebofScience数据库。进行荟萃分析，以生成抑郁症患者和对照组之间的汇总标准化平均差（SMD）和95％置信区间（CI）。敏感性分析,亚组分析，元回归，并进行了发表偏倚。
■共纳入18项研究，包括2,264名抑郁症患者和2,415名对照。与对照组相比，抑郁患者的NLR和PLR明显更高（SMD=0.33，95％CI：0.15-0.52，p<0.001，SMD=0.24，95％CI：0.02-0.46，p<0.05）。与对照组相比，抑郁个体的MLR略高（SMD=0.15，95％CI：-0.26至0.55，p>0.05），尽管没有意义。敏感性分析删除了一项导致异质性的研究，显示了MLR的更高且显着的影响（SMD=0.32，95％CI：0.20-0.44）。NLR的三个亚组分析，PLR,MLR,和抑郁症显示，中国抑郁症患者和对照组以及匹配的年龄和性别亚组之间的炎症比率存在明显差异。与非PSD患者相比，卒中后抑郁（PSD）患者的NLR和MLR值较高（SMD=0.51，95％CI：0.36-0.67，p<0.001，SMD=0.46，95％CI：0.12-0.79，p<0.01，分别）。Meta回归分析显示，病例组中男性比例影响了测量NLR值的研究之间的异质性（p<0.05）。
■较高的炎症比率，尤其是NLR,与抑郁症风险增加显著相关。在中国亚组中，年龄和性别相匹配，NLR,PLR,与抑郁症患者相比，MLR均升高controls.与非PSD患者相比，PSD患者的NLR和MLR值较高。性别差异可能对抑郁症患者的NLR值产生影响。
