PDF(Pubmed)
Abstract：
Systemic lupus erythematosus (SLE) is a complicated multiorgan disease and can lead to organ damage and increased risk of morbidity and mortality. The strategy of management while avoiding complications, especially caused by chronic glucocorticoid therapy, improves outcomes. Different definitions of the treatment goal in different configurations of lupus activity indexes have appeared over the years. In 2021 the definition of remission and recommendations for its achievement were published and it become a way to implement a treat-to-target strategy. The main goal of treatment has become DORIS (definition of remission in SLE) remission and the alternative LLDAS (low lupus disease activity state). Prolonging remission with clinical and immunological lupus activity restrictions and minimizing or stopping steroid doses reduced flares and damage accrual. The analysis and neutralization of poor prognosis predictive factors in lupus could be the most beneficial for less morbidity and mortality and better quality of life.
摘要：
系统性红斑狼疮（SLE）是一种复杂的多器官疾病，可导致器官损伤，发病率和死亡率增加。管理策略，同时避免并发症，特别是由慢性糖皮质激素治疗引起的，改善结果。多年来，在不同配置的狼疮活动指数中出现了不同的治疗目标定义。2021年，发布了缓解的定义和实现缓解的建议，并成为实施治疗目标战略的一种方式。治疗的主要目标已成为DORIS（SLE缓解的定义）缓解和替代LLDAS（低狼疮疾病活动状态）。在临床和免疫狼疮活动限制的情况下延长缓解，并尽量减少或停止类固醇剂量可减少耀斑和损害的发生。分析和消除狼疮不良预后预测因素可能对降低发病率和死亡率以及改善生活质量最有益。
