PDF(Pubmed)
Abstract：
The severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a life-threatening pandemic. Clinical evidence suggests that kidney involvement is common and might lead to mild proteinuria and even advanced acute kidney injury (AKI). Moreover, AKI caused by coronavirus disease 2019 (COVID-19) has been reported in several countries and regions, resulting in high patient mortality. COVID-19-induced kidney injury is affected by several factors including direct kidney injury mediated by the combination of virus and angiotensin-converting enzyme 2, immune response dysregulation, cytokine storm driven by SARS-CoV-2 infection, organ interactions, hypercoagulable state, and endothelial dysfunction. In this review, we summarized the mechanism of AKI caused by SARS-CoV-2 infection through literature search and analysis.
摘要：
严重的急性呼吸道冠状病毒2（SARS-CoV-2）已成为威胁生命的大流行。临床证据表明，肾脏受累是常见的，可能导致轻度蛋白尿，甚至晚期急性肾损伤（AKI）。此外，2019年冠状病毒病（COVID-19）引起的AKI已在多个国家和地区报告，导致患者死亡率高。COVID-19诱导的肾损伤受多种因素的影响，包括病毒和血管紧张素转换酶2联合介导的直接肾损伤，免疫反应失调，由SARS-CoV-2感染驱动的细胞因子风暴，器官相互作用，高凝状态，和内皮功能障碍。在这次审查中,通过文献检索和分析，总结了SARS-CoV-2感染引起AKI的机制。
