Abstract：
UNASSIGNED: The two ends of arteriovenous graft (AVG) are anastomosed to the upper limb vessels by surgery for hemodialysis therapy. However, the size of upper limb vessels varies to a large extent among different individuals.
UNASSIGNED: According to the shape and size of neck vessels quantified from the preoperative computed tomography angiographic scan, the ethylene-vinyl acetate (EVA)-based AVG was produced in H-shape by the three-dimensional (3D) printer and then sterilized. This study investigated the function of this novel 3D-printed AVG in vitro and in vivo.
UNASSIGNED: This 3D-printed AVG can be implanted in the rabbit\'s common carotid artery and common jugular vein with ease and functions in vivo. The surgical procedure was quick, and no suture was required. The blood loss was minimal, and no hematoma was noted at least 1 week after the surgery. The blood flow velocity within the implanted AVG was 14.9 ± 3.7 cm/s. Additionally, the in vitro characterization experiments demonstrated that this EVA-based biomaterial is biocompatible and possesses a superior recovery property than ePTFE after hemodialysis needle cannulation.
UNASSIGNED: Through the 3D printing technology, the EVA-based AVG can be tailor-made to fit the specific vessel size. This kind of 3D-printed AVG is functioning in vivo, and our results realize personalized vascular implants. Further large-animal studies are warranted to examine the long-term patency.
UNASSIGNED: According to the shape and size of neck vessels quantified from the preoperative computed tomography angiographic scan, the ethylene-vinyl acetate (EVA)-based AVG was produced in H-shape by the three-dimensional (3D) printer and then sterilized. This study investigated the function of this novel 3D-printed AVG in vitro and in vivo.
UNASSIGNED: This 3D-printed AVG can be implanted in the rabbit\'s common carotid artery and common jugular vein with ease and functions in vivo. The surgical procedure was quick, and no suture was required. The blood loss was minimal, and no hematoma was noted at least 1 week after the surgery. The blood flow velocity within the implanted AVG was 14.9 ± 3.7 cm/s. Additionally, the in vitro characterization experiments demonstrated that this EVA-based biomaterial is biocompatible and possesses a superior recovery property than ePTFE after hemodialysis needle cannulation.
UNASSIGNED: Through the 3D printing technology, the EVA-based AVG can be tailor-made to fit the specific vessel size. This kind of 3D-printed AVG is functioning in vivo, and our results realize personalized vascular implants. Further large-animal studies are warranted to examine the long-term patency.
摘要：
■动静脉移植物（AVG）的两端通过手术与上肢血管吻合，以进行血液透析治疗。然而,上肢血管的大小在不同的个体之间有很大的差异。
■根据术前计算机断层扫描血管造影扫描量化的颈部血管的形状和大小，通过三维(3D)打印机将乙烯-乙酸乙烯酯(EVA)基AVG制成H形,然后灭菌。这项研究调查了这种新型3D打印AVG在体外和体内的功能。
■这种3D打印的AVG可以轻松植入兔子的颈总动脉和颈总静脉，并在体内发挥功能。手术过程很快,不需要缝合。失血很少,手术后至少1周未发现血肿。植入的AVG内的血流速度为14.9±3.7cm/s。此外,体外表征实验表明，这种基于EVA的生物材料具有生物相容性，并且在血液透析针插管后比ePTFE具有更好的恢复性能。
■通过3D打印技术，基于EVA的AVG可以定制以适应特定的容器尺寸。这种3D打印的AVG在体内运行，我们的结果实现了个性化的血管植入。需要进一步的大型动物研究来检查长期通畅性。
■根据术前计算机断层扫描血管造影扫描量化的颈部血管的形状和大小，通过三维(3D)打印机将乙烯-乙酸乙烯酯(EVA)基AVG制成H形,然后灭菌。这项研究调查了这种新型3D打印AVG在体外和体内的功能。
■这种3D打印的AVG可以轻松植入兔子的颈总动脉和颈总静脉，并在体内发挥功能。手术过程很快,不需要缝合。失血很少,手术后至少1周未发现血肿。植入的AVG内的血流速度为14.9±3.7cm/s。此外,体外表征实验表明，这种基于EVA的生物材料具有生物相容性，并且在血液透析针插管后比ePTFE具有更好的恢复性能。
■通过3D打印技术，基于EVA的AVG可以定制以适应特定的容器尺寸。这种3D打印的AVG在体内运行，我们的结果实现了个性化的血管植入。需要进一步的大型动物研究来检查长期通畅性。
