Abstract：
Injecting-related skin and soft tissue infections (SSTIs) are a preventable cause of inpatient hospitalisation among people who inject drugs (PWID). This study aimed to determine the prevalence of hospitalisation for SSTIs among PWID, and identify similarities and differences in factors associated with hospitalisation for SSTIs versus non-bacterial harms related to injecting drug use.
We performed cross-sectional analyses of baseline data from an observational cohort study of PWID attending drug treatment clinics and needle and syringe programs in Australia. Logistic regression models were used to identify factors associated with self-reported hospitalisation for (1) SSTIs (abscess and/or cellulitis), and (2) non-bacterial harms related to injecting drug use (e.g., non-fatal overdose; hereafter referred to as non-bacterial harms), both together and separately.
1851 participants who injected drugs in the previous six months were enrolled (67% male; 85% injected in the past month; 42% receiving opioid agonist treatment [OAT]). In the previous year, 40% (n = 737) had been hospitalised for drug-related causes: 20% (n = 377) and 29% (n = 528) of participants were admitted to hospital for an SSTI and non-bacterial harm, respectively. Participants who were female (adjusted odds ratio [aOR]: 1.53, 95% CI: 1.19-1.97) or homeless (aOR: 1.59, 95% CI: 1.16-2.19) were more likely to be hospitalised for an SSTI, but not a non-bacterial harm. Both types of hospitalisation were more likely among people recently released from prison.
Hospitalisation for SSTIs is common among PWID. Community-based interventions to prevent SSTIs and subsequent hospitalisation among PWID will require targeting of at-risk groups, including women, people experiencing homelessness, and incarcerated people upon prison release.
We performed cross-sectional analyses of baseline data from an observational cohort study of PWID attending drug treatment clinics and needle and syringe programs in Australia. Logistic regression models were used to identify factors associated with self-reported hospitalisation for (1) SSTIs (abscess and/or cellulitis), and (2) non-bacterial harms related to injecting drug use (e.g., non-fatal overdose; hereafter referred to as non-bacterial harms), both together and separately.
1851 participants who injected drugs in the previous six months were enrolled (67% male; 85% injected in the past month; 42% receiving opioid agonist treatment [OAT]). In the previous year, 40% (n = 737) had been hospitalised for drug-related causes: 20% (n = 377) and 29% (n = 528) of participants were admitted to hospital for an SSTI and non-bacterial harm, respectively. Participants who were female (adjusted odds ratio [aOR]: 1.53, 95% CI: 1.19-1.97) or homeless (aOR: 1.59, 95% CI: 1.16-2.19) were more likely to be hospitalised for an SSTI, but not a non-bacterial harm. Both types of hospitalisation were more likely among people recently released from prison.
Hospitalisation for SSTIs is common among PWID. Community-based interventions to prevent SSTIs and subsequent hospitalisation among PWID will require targeting of at-risk groups, including women, people experiencing homelessness, and incarcerated people upon prison release.
摘要：
注射相关的皮肤和软组织感染（STTI）是注射药物（PWID）患者住院的可预防原因。这项研究旨在确定PWID中SSTIs的住院率，并确定与SUTI住院相关的因素和与注射药物使用相关的非细菌性危害的相似性和差异。
我们对澳大利亚PWID参加药物治疗诊所和针头和注射器项目的观察性队列研究的基线数据进行了横断面分析。使用Logistic回归模型来确定与自我报告住院相关的因素（1）SSTI（脓肿和/或蜂窝织炎），和（2）与注射毒品使用有关的非细菌危害（例如，非致命性用药过量；以下称为非细菌性危害），一起和分开。
1851名在过去6个月内注射药物的参与者入组（67%为男性；85%在过去一个月内注射；42%接受阿片类药物激动剂治疗[OAT]）。前一年,40％（n=737）因药物相关原因住院：20％（n=377）和29％（n=528）的参与者因SSTI和非细菌性伤害入院，分别。女性（调整后的比值比[aOR]：1.53，95％CI：1.19-1.97）或无家可归（aOR：1.59，95％CI：1.16-2.19）的参与者更有可能因SSTI住院，但不是非细菌伤害。在最近从监狱释放的人中，这两种类型的住院可能性更大。
STTI住院在PWID中很常见。以社区为基础的干预措施，以预防PWID中的SSTI和随后的住院，将需要针对高危人群，包括女性,经历无家可归的人，在监狱释放后被监禁的人。
我们对澳大利亚PWID参加药物治疗诊所和针头和注射器项目的观察性队列研究的基线数据进行了横断面分析。使用Logistic回归模型来确定与自我报告住院相关的因素（1）SSTI（脓肿和/或蜂窝织炎），和（2）与注射毒品使用有关的非细菌危害（例如，非致命性用药过量；以下称为非细菌性危害），一起和分开。
1851名在过去6个月内注射药物的参与者入组（67%为男性；85%在过去一个月内注射；42%接受阿片类药物激动剂治疗[OAT]）。前一年,40％（n=737）因药物相关原因住院：20％（n=377）和29％（n=528）的参与者因SSTI和非细菌性伤害入院，分别。女性（调整后的比值比[aOR]：1.53，95％CI：1.19-1.97）或无家可归（aOR：1.59，95％CI：1.16-2.19）的参与者更有可能因SSTI住院，但不是非细菌伤害。在最近从监狱释放的人中，这两种类型的住院可能性更大。
STTI住院在PWID中很常见。以社区为基础的干预措施，以预防PWID中的SSTI和随后的住院，将需要针对高危人群，包括女性,经历无家可归的人，在监狱释放后被监禁的人。
