UNASSIGNED: This study retrospectively reviewed 179 patients of PTC who underwent a thyroidectomy from January 2000 to June 2021 at Tianjin Medical University Cancer Hospital. We compared preoperative TgAb and TPOAb status with the clinicopathological features and prognosis of children and adolescents with PTC in different age groups.
UNASSIGNED: Patients with positive preoperative TPOAb and TgAb had lower recurrence rate in the younger group (P = 0.006, 0.047, respectively). Patients with positive TPOAb preoperatively had normal level of preoperative Tg and less cervical LNM than patients with negative TPOAb in children and adolescents (P < 0.05). Positive TPOAb preoperatively of PTC patients had a longer median DFS (113.4 months) than negative TPOAb (64.9 months) (P = 0.009, log-rank). Univariate analyses showed age, maximal tumor size, T stage, multifocality, lateral LNM and N staging were predictors for cancer recurrence in children and adolescents (P<0.05). Cox regression analysis found younger age (HR 0.224, P < 0.001), lateral LNM (HR 0.137, P = 0.010), N stage (HR 30.356, P < 0.001) were independent risk factors for recurrence.
UNASSIGNED: Our study found that presence of preoperative TPOAb and TgAb could serve as novel prognostic factors for predicting recurrence of PTC in children.
■本研究回顾性分析了2000年1月至2021年6月在天津医科大学肿瘤医院行甲状腺切除术的179例PTC患者。我们比较了术前TgAb和TPOAb状态与不同年龄段儿童和青少年PTC的临床病理特征和预后。
■术前TPOAb和TgAb阳性的患者在年轻组的复发率较低(P分别为0.006、0.047)。术前TPOAb阳性的患儿术前Tg水平正常,宫颈LNM低于TPOAb阴性的患儿(P<0.05)。PTC患者术前TPOAb阳性的中位DFS(113.4个月)比TPOAb阴性(64.9个月)更长(P=0.009,log-rank)。单变量分析显示年龄,最大肿瘤大小,T级,多焦点,外侧LNM和N分期是儿童和青少年癌症复发的预测因素(P<0.05)。Cox回归分析发现年龄较小(HR0.224,P<0.001),外侧LNM(HR0.137,P=0.010),N分期(HR30.356,P<0.001)是复发的独立危险因素。
■我们的研究发现术前TPOAb和TgAb的存在可以作为预测儿童PTC复发的新预后因素。