PDF(Pubmed)
Abstract：
The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG.
摘要：
特定分子畸变的鉴定指导2级星形细胞瘤的预后分层和处理。在大多数成人弥漫性低度神经胶质瘤（DLGG）中发现的异柠檬酸脱氢酶（IDH）1和2的突变，与IDH野生型（IDH-wt）对应物相比，似乎与良好的预后有关。此外，IDH-wt组可以发展额外的分子改变，恶化预后，例如表皮生长因子受体扩增（EGFR-amp）和端粒酶逆转录酶启动子（pTERT-mut）的突变。这篇综述分析了成年LGG遗传改变的预后影响和治疗意义。
